7-Hydroxyflavone
(Synonyms: 7羟基黄酮) 目录号 : GC63640
A flavonoid with diverse biological activities
Cas No.:6665-86-7
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >97.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
7-Hydroxyflavone is a plant flavonoid that has diverse biological activities.1,2,3,4 It inhibits enterovirus 71 (EV71) replication in infected RD cells (EC50 = 19.95 ?M).1 7-Hydroxyflavone (20 ?M) reduces nicotine-induced production of reactive oxygen species (ROS) and cytotoxicity in NRK-52E cells.2 It inhibits LPS-induced production of nitric oxide (NO), prostaglandin E2 , TNF-α, and IL-6 in RAW 264.7 cells.3 In vivo, 7-hydroxyflavone reduces acetic acid-induced writhing in mice (ED50 = 125 mg/kg).4
1.Wang, J., Su, H., Zhang, T., et al.Inhibition of enterovirus 71 replication by 7-hydroxyflavone and diisopropyl-flavon7-yl phosphatePLoS One9(3)e92565(2014) 2.Sengupta, B., Sahihi, M., Dehkhodaei, M., et al.Differential roles of 3-hydroxyflavone and 7-hydroxyflavone against nicotine-induced oxidative stress in rat renal proximal tubule cellsPLoS One12(6)e0179777(2014) 3.Jin, Z., Yang, Y.-Z., Chen, J.-X., et al.Inhibition of pro-inflammatory mediators in RAW264.7 cells by 7-hydroxyflavone and 7,8-dihydroxyflavoneJ. Pharm. Pharmacol.69(7)865-874(2017) 4.Thirugnanasambantham, P., Viswanathan, S., Mythirayee, C., et al.Analgesic activity of certain flavone derivatives: A structure-activity studyJ. Ethnopharmacol.28(2)207-214(1990)
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.1974 mL | 20.9872 mL | 41.9745 mL |
| 5 mM | 0.8395 mL | 4.1974 mL | 8.3949 mL |
| 10 mM | 0.4197 mL | 2.0987 mL | 4.1974 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。