740 Y-P

740 Y-P is an activator of PI3K with concentration of 20 μM [1].
PI3K (phosphoinositide 3-kinases, PI3Ks) is an enzyme and plays an important role in the fundamental cellular processes, such as vesicular trafficking, cell degranulation, cell migration, and glucose transporter. It has been reported that over-expression of PI3K was correlated with a variety kind of cancers [2].
740 Y-P is a potent PI3K activator and plays an important role in PI3K/AKT signaling pathway. When tested with human melanoma MNT-1 cells, 20 μM 740 Y-P for 24 hours treatment significantly reduced the number of M6PR-positive vacuoles induced by sucrose via activating PI3K [1]. In cerebellar granule cells in the circumstance of serum deprivation, 740 Y-P treatments reduced the cell death rate via binding to p85 which was correlated with PI 3-kinase-dependent phosphorylation of Akt process [3].

References:
[1]. Bin, B.H., et al., Hyperosmotic stress reduces melanin production by altering melanosome formation. PLoS One, 2014. 9(8): p. e105965.
[2]. Kong, B., et al., A subset of metastatic pancreatic ductal adenocarcinomas depends quantitatively on oncogenic Kras/Mek/Erk-induced hyperactive mTOR signalling. Gut, 2015.
[3]. Williams, E.J. and P. Doherty, Evidence for and against a pivotal role of PI 3-kinase in a neuronal cell survival pathway. Mol Cell Neurosci, 1999. 13(4): p. 272-80.

740 Y-P是一种PI3K激活剂，浓度为20μM [1]。PI3K（磷脂酰肌醇3-激酶）是一种酶，在细胞基本过程中发挥重要作用，如囊泡运输、细胞去颗粒化、细胞迁移和葡萄糖转运。已有报道称，PI3K的过表达与多种癌症相关[2]。 740 Y-P是一种有效的PI3K激活剂，在PI3K/AKT信号通路中发挥重要作用。当在人黑色素瘤MNT-1细胞中测试时，使用20μM 740 Y-P处理24小时可显着减少由蔗糖诱导的M6PR阳性液泡数量，并通过激活PI3K实现[1]。在血清匮乏情况下的小脑颗粒神经元中，使用740 Y-P处理可以通过结合与与 PI 3-kinase 相关联的 p85 来降低死亡率，并促进 Akt 进程上 PI 3-kinase依赖性的磷酸化[3]。