8-Gingerol

8-Gingerol is a natural chemical found in the rhizomes of ginger (Z. officinale). It contains the same aromatic region and polar link but has a longer hydrophobic tail than the more abundant 6-gingerol . Like 6-gingerol, 8-gingerol activates the transient receptor potential vanilloid receptor 1 (TRPV1; EC₅₀ = 5.0 ?M), inhibits COX-2, and inhibits the growth of H. pylori in vitro.^1,2 8-Gingerol also augments wound healing, suppresses IL-2-induced proliferation of T lymphocytes, and potentiates β-agonist-induced relaxation of airway smooth muscle.^3,4,5 Oral 8-gingerol is expected to be readily absorbed and rapidly metabolized by glucuronidation and sulfation, with minimal to modest effects on cytochrome P450 isoforms.^6,7

1.Dedov, V.N., Tran, V.H., Duke, C.C., et al.Gingerols: a novel class of vanilloid receptor (VR1) agonistsBr. J. Pharmacol.137(6)793-798(2002) 2.Chrubasik, S., Pittler, M.H., and Roufogalis, B.D.Zingiberis rhizoma: A comprehensive review on the ginger effect and efficacy profilesPhytomedicine12(9)684-701(2005) 3.Bakht, M.A., Alajmi, M.F., Alam, P., et al.Theoretical and experimental study on lipophilicity and wound healing activity of ginger compoundsAsian Pac. J. Trop. Biomed.4(4)329-333(2014) 4.Bernard, M., Furlong, S.J., Power Coombs, M.R., et al.Differential inhibition of T lymphocyte proliferation and cytokine synthesis by [6]-Gingerol, [8]-Gingerol, and [10]-GingerolPhytother. Res.29(11)1707-1713(2015) 5.Townsend, E.A., Zhang, Y., Xu, C., et al.Active components of ginger potentiate β-agonist-induced relaxation of airway smooth muscle by modulating cytoskeletal regulatory proteinsAm. J. Respir. Cell Mol. Biol.50(1)115-124(2014) 6.Mukkavilli, R., Gundala, S.R., Yang, C., et al.Modulation of cytochrome P450 metabolism and transport across intestinal epithelial barrier by ginger biophenolicsPLoS One9(9)e108386(2014) 7.Qiu, J.-X., Zhou, Z.-W., He, Z.-X., et al.Estimation of the binding modes with important human cytochrome P450 enzymes, drug interaction potential, pharmacokinetics, and hepatotoxicity of ginger components using molecular docking, computational, and pharmacokinetic modeling studiesDrug Des. Devel. Ther.9841-866(2015)