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8-Methoxypsoralen Sale

(Synonyms: 甲氧沙林; 8-Methoxypsoralen; Xanthotoxin; 8-MOP) 目录号 : GN10330

8-Methoxypsoralen (8-Methoxypsoralen) 是一种有效的 CYP(细胞色素 P-450)三环呋喃香豆素自杀抑制剂,是一种用于治疗银屑病、湿疹、白癜风和一些皮肤淋巴瘤以及将皮肤暴露在阳光下的药物。

8-Methoxypsoralen Chemical Structure

Cas No.:298-81-7

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥452.00
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20mg
¥1,071.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Methoxsalen (8-Methoxypsoralen) is a potent tricyclic furocoumarin suicide inhibitor of CYP (cytochrome P-450), is an agent used to treat psoriasis, eczema, vitiligo and some cutaneous Lymphomas in conjunction with exposing the skin to sunlight.Target: CYP (cytochrome P-450)Methoxsalen is a drug used to treat psoriasis, eczema, vitiligo, and some cutaneous lymphomas in conjunction with exposing the skin to UVA light from lamps or sunlight. Methoxsalen modifies the way skin cells receive the UVA radiation, allegedly clearing up the disease. The dosage comes in 10 mg tablets, which are taken in the amount of 30 mg 75 minutes before a PUVA (psoralen + UVA) light treatment. Chemically, methoxsalen belongs to a class of organic natural molecules known asfuranocoumarins. They consist of coumarin annulated with furan.Administration of intra peritoneal (ip) methoxsalen significantly increased nicotine's Cmax, prolonged the plasma half-life (fourfold decrease) of nicotine, and increased its area under the curve (AUC) compared with ip vehicle treatment. Methoxsalen pretreatment prolonged the duration of nicotine-induced antinociception and hypothermia (15mg/kg, po) for periods up to 6- and 24-hr postnicotine administration, respectively.

References:
[1]. Alsharari SD, et al. Pharmacokinetic and Pharmacodynamics Studies of Nicotine After Oral Administration in Mice: Effects of Methoxsalen, a CYP2A5/6 Inhibitor. Nicotine Tob Res. 2014 Jan;16(1):18-25.

Chemical Properties

Cas No. 298-81-7 SDF
别名 甲氧沙林; 8-Methoxypsoralen; Xanthotoxin; 8-MOP
化学名 9-methoxyfuro[3,2-g]chromen-7-one
Canonical SMILES COC1=C2C(=CC3=C1OC=C3)C=CC(=O)O2
分子式 C12H8O4 分子量 216.19
溶解度 ≥ 6.5mg/mL in DMSO 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.6256 mL 23.1278 mL 46.2556 mL
5 mM 0.9251 mL 4.6256 mL 9.2511 mL
10 mM 0.4626 mL 2.3128 mL 4.6256 mL
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第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量)
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