Home>>Lipids>> Cyclooxygenase>>9-keto Fluprostenol isopropyl ester

9-keto Fluprostenol isopropyl ester Sale

(Synonyms: 9-酮氟前列醇异丙酯) 目录号 : GC42647

A potential EP agonist in prodrug form

9-keto Fluprostenol isopropyl ester Chemical Structure

Cas No.:1219032-18-4

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1mg
¥1,216.00
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5mg
¥5,482.00
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10mg
¥9,730.00
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Sample solution is provided at 25 µL, 10mM.

Description

Fluprostenol is a well-studied, potent analog of prostaglandin F2α (PGF2α) and acts primarily through the FP receptor. Oxidation at C-9 of fluprostenol yields 9-keto fluprostenol. Prostaglandin esters are known to be hydrolyzed in the eye to the corresponding free acids. However, the use of prostaglandin esters as prodrugs outside the eye is relatively unexplored. 9-keto Fluprostenol is an analog of PGE2 with structural modifications intended to give it a prolonged half-life and greater potency. 9-keto Fluprostenol isopropyl ester has the potential to act as an EP agonist in prodrug form. However, no studies on the pharmacology of this compound have been published to date. In addition 9-keto fluprostenol isopropyl ester is a potential metabolite of Travoprost, which is the Alcon trade name for fluprostenol isopropyl ester. In monkey cornea, this transformation was observed as a product of NADP+-dependent 15-hydroxyprostaglandin dehydrogenase when the closely related analog Latanoprost was used as a substrate. Certain F-series prostaglandins have been shown to be converted to the corresponding E-series compounds in rabbit liver and human platelet preparations.

化学性质

Cas No. 1219032-18-4 SDF
别名 9-酮氟前列醇异丙酯
Canonical SMILES O[C@H]1[C@H](/C=C/[C@@H](O)COC2=CC(C(F)(F)F)=CC=C2)[C@@H](C/C=C\CCCC(OC(C)C)=O)C(C1)=O
分子式 C26H33F3O6 分子量 498.5
溶解度 DMF: 30 mg/ml,DMF:PBS (1:1): 500 µ g/ml,DMSO: 20 mg/ml,Ethanol: 25 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.006 mL 10.0301 mL 20.0602 mL
5 mM 0.4012 mL 2.006 mL 4.012 mL
10 mM 0.2006 mL 1.003 mL 2.006 mL
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