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α-CGRP (human) (trifluoroacetate salt) Sale

(Synonyms: α-Calcitonin Gene-Related Peptide (human), Calcitonin Gene Related Peptide-1 (human), CGRP-1 (human)) 目录号 : GC45199

A neuropeptide with diverse biological activities

α-CGRP (human) (trifluoroacetate salt) Chemical Structure

规格 价格 库存 购买数量
500μg
¥2,431.00
现货
1mg
¥4,374.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

α-Calcitonin gene-related peptide (α-CGRP) is a neuropeptide with diverse biological activities. It belongs to the calcitonin family of peptides, which also includes amylin , calcitonin , and adrenomedullin. α-CGRP binds selectively to a heteromeric complex of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1; IC50 = 0.1 nM) over a complex of CLCR and RAMP2 (IC50 = 1,300 nM). It also binds selectively to complexes of human calcitonin receptor 2 (CTR2) and RAMP1 (IC50 = 43.7 nM) compared to CTR2 and RAMP2 complexes (IC50 = 141.3 nM) in amylin radioligand displacement assays. α-CGRP induces cAMP-activated currents in Xenopus oocytes with endogenous Cgrp receptors that overexpress RAMP1 (EC50 = 9 nM). It also induces cAMP accumulation in COS-7 cells transfected with both CTR2 and RAMP1 (EC50 = 8.32 nM).

Chemical Properties

Cas No. SDF
别名 α-Calcitonin Gene-Related Peptide (human), Calcitonin Gene Related Peptide-1 (human), CGRP-1 (human)
分子式 C163H267N51O49S2•XCF3COOH 分子量 3789.3
溶解度 Water: 1 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.2639 mL 1.3195 mL 2.639 mL
5 mM 0.0528 mL 0.2639 mL 0.5278 mL
10 mM 0.0264 mL 0.132 mL 0.2639 mL
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