α-Muricholic Acid-d4

α-Muricholic acid-d₄ is intended for use as an internal standard for the quantification of α-muricholic acid by GC- or LC-MS. α-Muricholic acid is a murine-specific primary bile acid.^1,2 Dietary administration of soybean protein decreases fecal levels of α-muricholic acid in mice with high-fat diet-induced obesity, which correlates with increases in fecal Clostridium cluster XIVa, a major producer of secondary bile acids.³ Plasma, liver, and muscle levels of α-muricholic acid are increased in mice switched from a high-fat to low-fat diet.⁴

1.Eyssen, H.J., Parmentier, G.G., and Mertens, J.A.Sulfate bile acids in germ-free and conventional miceEur. J. Biochem.66(3)507-514(1976) 2.Uehara, T., Xi Peng, X., Bennett, B., et al.c-Jun N-terminal kinase mediates hepatic injury after rat liver transplantationTransplantation78(3)324-332(2004) 3.Watanabe, K., Igarashi, M., Li, X., et al.Dietary soybean protein ameliorates high-fat diet-induced obesity by modifying the gut microbiota-dependent biotransformation of bile acidsPLoS One13(8)e0202083(2018) 4.La Frano, M.R., Hernandez-Carretero, A., Weber, N., et al.Diet-induced obesity and weight loss alter bile acid concentrations and bile acid-sensitive gene expression in insulin target tissues of C57BL/6J miceNutr. Res.4611-21(2017)