β-CGRP (human) (trifluoroacetate salt)
(Synonyms: α-Calcitonin Gene-Related Peptide (human), Calcitonin Gene Related Peptide-1 (human), CGRP-1 (human)) 目录号 : GC45227A neuropeptide with diverse biological activities
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
β-Calcitonin gene-related peptide (β-CGRP) is a neuropeptide with roles in vasodilation, cardiovascular regulation, and inflammation. It belongs to the calcitonin family of peptides, which also includes α-CGRP , amylin , calcitonin , and adrenomedullin. β-CGRP binds selectively to a heteromeric complex of calcitonin receptor-like receptor (CRLR) and receptor activity-modifying protein 1 (RAMP1; IC50 = 0.01 nM) over a complex of CLCR and RAMP2 (IC50 = 300 nM). It binds to rat brain and spleen membrane preparations (IC50s = 1.1 and 1 nM, respectively) and relaxes human cerebral and middle meningeal arterial segments precontracted with prostaglandin F2α . In vivo, β-CGRP induces a 50% increase in diameter of arterioles precontracted with human endothelin-1 in hamster cheek pouch at a concentration of 15.8 pM.
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 0.2636 mL | 1.3181 mL | 2.6362 mL |
| 5 mM | 0.0527 mL | 0.2636 mL | 0.5272 mL |
| 10 mM | 0.0264 mL | 0.1318 mL | 0.2636 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。