γ1-MSH (human, mouse, rat, bovine) (trifluoroacetate salt)
(Synonyms: γ1-Melanocyte-stimulating Hormone) 目录号 : GC92101γ1-MSH (human, mouse, rat, bovine) (trifluoroacetate salt)是一种肽激素，由垂体中的前皮黑皮质素（POMC）翻译后加工产生。
Sample solution is provided at 25 µL, 10mM.
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γ1-Melanocyte-stimulating hormone (γ1-MSH) is a peptide hormone produced by post-translational processing of proopiomelanocortin (POMC) in the pituitary gland.1 It selectively binds to melanocortin receptor 1 (MC1R) and MC3R over MC4R and MC5R (Kis = 0.025, 0.063, >100, and >100 ?M, respectively, in insect cells expressing the human receptors) but also binds to opioid receptors in rat brain tissue homogenates (IC50 = 5.9 ?M).2,3 γ1-MSH (10 ?M) inhibits contractions induced by the neuropeptide FMRF-amide in isolated M. edulis catch muscle.4 Intracisternal administration of γ1-MSH (0.3 nmol/animal) increases the latency to tail flick in the tail-flick test and inhibits haloperidol-induced catalepsy in mice.5 γ1-MSH (0.01 nmol/animal) also inhibits LPS-induced nitric oxide (NO) release in mouse forebrain in vivo.2
References:
[1]. Rubakhin, S.S., Churchill, J.D., Greenough, W.T., et al.Profiling signaling peptides in single mammalian cells using mass spectrometryAnal. Chem.78(20)7267-7272(2006).
[2]. Muceniece, R., Zvejniece, L., Liepinsh, E., et al.The MC3 receptor binding affinity of melanocortins correlates with the nitric oxide production inhibition in mice brain inflammation modelPeptides27(6)1443-1450(2006).
[3]. Oki, S., Nakao, K., Nakai, Y., et al.'γ-MSH' fragments from ACTH-beta-LPH precursor have an affinity for opiate receptorsEur. J. Pharmacol.64(2-3)161-164(1980).
[4]. Muneoka, Y., and Saitoh, H.Pharmacology of FMRFamide in Mytilus catch muscleComp. Biochem. Physiol. C Comp. Pharmacol. Toxicol.85(1)207-214(1986).
[5]. Klusa, V., Germane, S., Svirskis, S., et al.The γ2-MSH peptide mediates a central analgesic effect via a GABA-ergic mechanism that is independent from activation of melanocortin receptorsNeuropeptides35(1)50-57(2001).
| Cas No. | SDF | ||
| 别名 | γ1-Melanocyte-stimulating Hormone | ||
| 化学名 | L-tyrosyl-L-valyl-L-methionylglycyl-L-histidyl-L-phenylalanyl-L-arginyl-L-tryptophyl-L-α-aspartyl-L-arginyl-L-phenylalaninamide, trifluoroacetate salt | ||
| Canonical SMILES | O=C([C@H](CC1=CNC2=CC=CC=C21)NC([C@@H](NC([C@H](CC3=CC=CC=C3)NC([C@H](CC4=CN=CN4)NC(CNC([C@@H](NC([C@@H](NC([C@H](CC5=CC=C(O)C=C5)N)=O)C(C)C)=O)CCSC)=O)=O)=O)=O)CCCNC(N)=N)=O)N[C@H](C(N[C@H](C(N[C@@H](CC6=CC=CC=C6)C(N)=O)=O)CCCNC(N)=N)=O)CC(O)=O.O=C(O)C(F)(F)F | ||
| 分子式 | C72H97N21O14S ? XCF3COOH | 分子量 | 1512.7 |
| 溶解度 | DMSO: Soluble: ≥10 mg/ml,PBS (pH 7.2): Soluble: ≥10 mg/ml | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.6611 mL | 3.3053 mL | 6.6107 mL |
| 5 mM | 0.1322 mL | 0.6611 mL | 1.3221 mL |
| 10 mM | 0.0661 mL | 0.3305 mL | 0.6611 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet