γ-Glu-Ala (trifluoroacetate salt)
(Synonyms: γ-Glutamylalanine, γ-L-Glutamyl-L-alanine) 目录号 : GC52400A dipeptide
Sample solution is provided at 25 µL, 10mM.
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γ-Glu-Ala is an endogenous kokumi dipeptide composed of L-glutamic acid and L-alanine that has been found in P. roqueforti.1 It has also been found in several ripened cheeses, including Gouda, goat, and Milner cheeses. γ-Glu-Ala is a positive allosteric modulator of the calcium-sensing receptor (CaSR; EC50 = 4.8 µM in CaSR-expressing HEK293 cells).2 It induces glutathionuria in mice when administered at a dose of 4 mmol/kg.3 Plasma levels of γ-Glu-Ala are increased in malnourished neonatal mice.4 Increased serum levels of γ-Glu-Ala are positively associated with an increased risk of chronic kidney disease.5
1.Toelstede, S., and Hofmann, T.Kokumi-active glutamyl peptides in cheeses and their biogeneration by Penicillium roquefortiiJ. Agric. Food Chem.57(9)3738-3748(2009) 2.Broadhead, G.K., Mun, H.-C., Avlani, V.A., et al.Allosteric modulation of the calcium-sensing receptor by γ-glutamyl peptides: Inhibition of PTH secretion, suppression of intracellular cAMP levels, and a common mechanism of action with ?-amino acidsJ. Biol. Chem.286(11)8786-8797(2011) 3.Anderson, M.E., and Meister, A.Inhibition of γ-glutamyl transpeptidase and induction of glutathionuria by γ-glutamyl amino acidsProc. Natl. Acad. Sci. USA83(14)5029-5032(1986) 4.Preidis, G.A., Keaton, M.A., Campeau, P.M., et al.The undernourished neonatal mouse metabolome reveals evidence of liver and biliary dysfunction, inflammation, and oxidative stressJ. Nutr.144(3)273-281(2014) 5.Kim, H., Yu, B., Li, X., et al.Serum metabolomic signatures of plant-based diets and incident chronic kidney diseaseAm. J. Clin. Nutr.116(1)151-164(2022)
| Cas No. | SDF | Download SDF | |
| 别名 | γ-Glutamylalanine, γ-L-Glutamyl-L-alanine | ||
| Canonical SMILES | OC([C@@H](N)CCC(N[C@@H](C)C(O)=O)=O)=O.OC(C(F)(F)F)=O | ||
| 分子式 | C8H14N2O5 ? XCF3COOH | 分子量 | 218.2 |
| 溶解度 | DMF: 3 mg/ml,DMSO: 5 mg/ml,Ethanol: 16 mg/ml,PBS (pH 7.2): 1 mg/ml | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.583 mL | 22.9148 mL | 45.8295 mL |
| 5 mM | 0.9166 mL | 4.583 mL | 9.1659 mL |
| 10 mM | 0.4583 mL | 2.2915 mL | 4.583 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet