α-Cembrenediol
(Synonyms: α-CBD) 目录号 : GC26654α-Cembrenediol is a diterpenoid that has been found in N. tabacum and has diverse biological activities.
Cas No.:57605-80-8
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >90.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
α-Cembrenediol is a diterpenoid that has been found in N. tabacum and has diverse biological activities.[1,2,3,4]
It inhibits induction of the early antigen of Epstein-Barr virus (EA-EBV) by 12-O-tetradecanoylphorbol-13-acetate (TPA) in Raji cells (IC50 = 25.2 μM).[2]
α-Cembrenediol is active against the plant pathogenic fungus V. mali (IC50 = 18 mg/L).[3]
Dermal application of α-cembrenediol (3.3 µmol) reduces the tumor promoting effects of TPA on 7,12-demethylbenz[a]anthracene-induced papilloma formation by 53% in mice.[4] It has been found in cigarette smoke condensate.
References:
[1]. Sui, J., Wang, C., Liu, X., et al. Formation of α- and β-cembratriene-diols in tobacco (Nicotiana tabacum L.) is regulated by jasmonate-signaling components via manipulating multiple cembranoid synthetic genes. Molecules 23(10), 2511 (2018).
[2]. Saito, Y., Tsujino, Y., Kaneko, H., et al. Inhibitory effects of cembratriene-4,6-diol derivatives on the induction of Epstein-Barr virus early antigen by 12-O-tetradecanoylphorbol-13-acetate. Agric. Biol. Chem. 51(3), 941-943 (1987).
[3]. Yan, N., Du, Y., Liu, X., et al. Analyses of effects of α-cembratrien-diol on cell morphology and transcriptome of Valsa mali var. mali. Food Chem. 214, 110-118 (2017).
[4]. Saito, Y., Takizawa, H., Konishi, S., et al. Identification of cembratriene-4,6-diol as antitumor-promoting agent from cigarette smoke condensate. Carcinogenesis 6(8), 1189-1194 (1985).
| Cas No. | 57605-80-8 | SDF | |
| 别名 | α-CBD | ||
| 分子式 | C20H34O2 | 分子量 | 306.5 |
| 溶解度 | Chloroform: Slightly soluble; Methanol: Slightly soluble | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 3.2626 mL | 16.3132 mL | 32.6264 mL |
| 5 mM | 0.6525 mL | 3.2626 mL | 6.5253 mL |
| 10 mM | 0.3263 mL | 1.6313 mL | 3.2626 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。