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Abeprazan Sale

(Synonyms: 非苏拉赞,DWP14012; Fexuprazan) 目录号 : GC62823

Abeprazan (DWP14012) 是一种钾竞争性酸 (potassium-competitive acid) 阻滞剂。Abeprazan 通过可逆的钾竞争性离子结合抑制 H+,K+- ATPase,而无需酸激活。Abeprazan 是一种潜在的质子泵抑制剂,用于研究与酸相关的疾病。

Abeprazan Chemical Structure

Cas No.:1902954-60-2

规格 价格 库存 购买数量
1mg
¥738.00
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2mg
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5mg
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10mg
¥2,770.00
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25mg
¥4,310.00
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50mg
¥5,830.00
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100mg
¥7,740.00
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Sample solution is provided at 25 µL, 10mM.

Description

Abeprazan (DWP14012) is a potassium-competitive acid blocker. Abeprazan inhibits H+, K+- ATPase by reversible potassium-competitive ionic binding with no acid activation required. Abeprazan is developed as a potential alternative to proton pump inhibitor for the treatment of acid-related diseases[1].

The mechanism of action of Abeprazan is reversibly binding to H+, K+‐ATPase, and, unlike that of PPIs, does not require acidic environment for drug activation[1].

DWP14012 inhibited acid secretion in a dose-dependent manner and the inhibition of gastric acid secretion was equal to or greater than that of vonoprazan, a previously approved P-CAB, in various in vivo studies using pylorus-ligated rats, lumen-perfused rat models and heidenhain pouch dog models[1].

[1]. Sunwoo J, et al. Safety, tolerability, pharmacodynamics and pharmacokinetics of DWP14012, a novel potassium-competitive acid blocker, in healthy male subjects. Aliment Pharmacol Ther. 2018 Jul;48(2):206-218.

化学性质

Cas No. 1902954-60-2 SDF
别名 非苏拉赞,DWP14012; Fexuprazan
分子式 C19H17F3N2O3S 分子量 410.41
溶解度 DMSO : 50 mg/mL (121.83 mM; Need ultrasonic) 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 2.4366 mL 12.1829 mL 24.3659 mL
5 mM 0.4873 mL 2.4366 mL 4.8732 mL
10 mM 0.2437 mL 1.2183 mL 2.4366 mL
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