ACE2 (18-740) Human, Biotin
目录号 : GP26118The HEK293 derived ACE2 Human recombinant biotinylated protein contains the amino acids Gln 18-Ser 740 fused to His-AVI tag at C-terminal having a predicted Mw of 87
Sample solution is provided at 25 µL, 10mM.
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The HEK293 derived ACE2 Human recombinant biotinylated protein contains the amino acids Gln 18-Ser 740 fused to His-AVI tag at C-terminal having a predicted Mw of 87.2 kDa ( migrates 95-125 kDa under reducing conditions on sds-page due to glycosilation).ACE2 Protein binds to SARS Coronavirus-2 [ CoV-2019 ] Spike receptor binding domain.
| Purity | ACE-2 Protein is >90% pure as determined SDS-PAGE. | Source | HEK293Cells |
| Phycical Appearance | Sterile Filtered clear solution. | Shipping Condition | withIcePacks |
| Stability | ACE-2 Human RecombinantProtein is shipped on ice packs. Upon arrival, Store at -20°C. The addition of 0.1% albmin is highly recommended for long term storage use. | ||
| Biological Activity | ACE2 activity was measured by its binding ability in a functional ELISA.The immobilized Recombinant Human ACE2 protein binds to SARS CoV2 Spike proteinReceptor Binding Domain at 2ug per ml. | ||
| Formulation | ACE2 Humanprotein solution is supplied in 50mM Tris, pH7.5, 150mM NaCl and 20% glycerol. | ||
ACE-2 (Angiotensin converting enzyme 2) an enzyme bound to cell membranes in various organs such as intestines arteries , lungs, heart & kidney. ACE2 an entry receptor of SARS coronaviruses as well as SARS-CoV-2,.The coronavirus spike (S) glycoprotein is a class I viral fusion antigen located on the external envelope of the virion that takes part in a critical part in viral infection by identifying host cell receptors and facilitating fusion of the viral and cellular membranes. 2 main domains in coronavirus S1 have been recognized, the N-terminal domain and C-terminal domain. One or the other and/or both S1 domains function as a receptor-binding domain. SARS-CoV + MERS-CoV equally use C-domain to attach their receptors.ACE2 is a type I transmembrane antigen with an extracellular N-terminal domain having the catalytic site and an intracellular C-terminal tail. ACE2 obtains a signal peptide, a transmembrane domain, and a single metalloproteinase active site containing an HEXXH zinc-binding domain. ACE-2 plays a role as a mono-carboxypeptidase which degrades Ang I to produce the nonapeptide Ang 1–9 and Ang II to create the heptapeptide Ang 1–7.
ACE2 activity was measured by its binding ability in a functional ELISA.The immobilized Recombinant Human ACE2 protein binds to SARS CoV2 Spike proteinReceptor Binding Domain at 2ug per ml.
Purified by Protein-G chromatographic technique.
ACE-2 Human RecombinantProtein is shipped on ice packs. Upon arrival, Store at -20°C. The addition of 0.1% albmin is highly recommended for long term storage use.