Acetyl-Coenzyme A-d3 (sodium salt)
(Synonyms: Acetyl-CoA-d3) 目录号 : GC91813Acetyl-coenzyme A-d3 (acetyl-CoA-d3) is intended for use as an internal standard for the quantification of acetyl-CoA by GC- or LC-MS.
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Acetyl-coenzyme A-d3 (acetyl-CoA-d3) is intended for use as an internal standard for the quantification of acetyl-CoA by GC- or LC-MS. Acetyl-CoA, the thioester of CoA and acetic acid, is a pivotal molecule in biological systems. Foremost, it serves as a source of carbon for the Krebs cycle, for the synthesis of fatty acids, and for isoprenoid-based protein modifications.1,2,3,4 Acetyl-CoA also serves as an intermediate in oxidation of fatty acids and amino acids and is formed by the oxidative decarboxylation of pyruvate in mitochondria.[5] It is an essential cofactor or substrate for acetyltransferases and acyltransferases, as in the post-translational modification of proteins and in the synthesis of the neurotransmitter acetylcholine.2,3
References:
[1].Akram, M.Citric acid cycle and role of its intermediates in metabolismCell Biochem. Biophys.68(3)475-478(2014).
[2].Salminen, A., Kauppinen, A., Hiltunen, M., et al.Krebs cycle intermediates regulate DNA and histone methylation: Epigenetic impact on the aging processAgeing Res. Rev.16C45-65(2014).
[3].Zaidi, N., Swinnen, J.V., and Smans, K.ATP-citrate lyase: A key player in cancer metabolismCancer Res.72(15)3709-3714(2012).
[4].Palsson-McDermott, E.M., and O'Neill, L.A.The Warburg effect then and now: From cancer to inflammatory diseasesBioEssays35(11)965-973(2013).
[5].Miura, Y.The biological significance of ω-oxidation of fatty acidsProc. Jpn. Acad. Ser. B Phys. Biol. Sci.89(8)370-382(2013).
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.2306 mL | 6.1531 mL | 12.3062 mL |
| 5 mM | 0.2461 mL | 1.2306 mL | 2.4612 mL |
| 10 mM | 0.1231 mL | 0.6153 mL | 1.2306 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。