Acetyl Coenzyme A (sodium salt)
(Synonyms: 乙酰辅酶A钠盐; Acetyl-CoA trisodium) 目录号 : GC42697
乙酰辅酶A钠盐（Acetyl Coenzyme A (sodium salt)）是酶促乙酰基转移反应中必需的辅因子和酰基载体。Acetyl Coenzyme A 可作为组蛋白乙酰酶（HAT）的乙酰基供体，用于组蛋白和非组蛋白的翻译后乙酰化反应。
Cas No.:102029-73-2
Sample solution is provided at 25 µL, 10mM.
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Acetyl Coenzyme A (sodium salt) is an essential cofactor and acyl carrier in enzymatic acetyl transfer reactions[1]. Acetyl Coenzyme A can serve as an acetyl donor for histone acetylase (HAT) for post-translational acetylation of histones and non-histone proteins[2]. Acetyl Coenzyme A is formed by the oxidative decarboxylation of pyruvate in mitochondria, the oxidation of long-chain fatty acids, or the oxidative degradation of certain amino acids[3]. Acetyl Coenzyme A is the starting compound of the citric acid cycle (Kreb cycle), a key precursor for lipid biosynthesis, and the source of all fatty acid carbons[4]. Acetyl Coenzyme A positively regulates the activity of pyruvate carboxylase[5]. Acetyl Coenzyme A is a precursor of the neurotransmitter acetylcholine[6].
References:
[1] Masiarz F R. Acyl-coenzyme-a: Coenzyme-a Acyltransferase--a Novel Mammalian Enzyme[M]. University of Michigan, 1973.
[2] Takahashi H, McCaffery J M, Irizarry R A, et al. Nucleocytosolic acetyl-coenzyme a synthetase is required for histone acetylation and global transcription[J]. Molecular cell, 2006, 23(2): 207-217.
[3] Abo Alrob O, Lopaschuk G D. Role of CoA and acetyl-CoA in regulating cardiac fatty acid and glucose oxidation[J]. Biochemical Society Transactions, 2014, 42(4): 1043-1051.
[4] Kumar P, Dubey K K. Citric acid cycle regulation: Back bone for secondary metabolite production[M]//New and Future Developments in Microbial Biotechnology and Bioengineering. Elsevier, 2019: 165-181.
[5] Numa S, Tanabe T. Acetyl-coenzyme A carboxylase and its regulation[M]New comprehensive biochemistry. Elsevier, 1984, 7: 1-27.
[6] Szutowicz A, Bielarczyk H, Jankowska-Kulawy A, et al. Acetyl-CoA the key factor for survival or death of cholinergic neurons in course of neurodegenerative diseases[J]. Neurochemical research, 2013, 38: 1523-1542.
| Cas No. | 102029-73-2 | SDF | |
| 别名 | 乙酰辅酶A钠盐; Acetyl-CoA trisodium | ||
| Canonical SMILES | O[C@H]1[C@H](N2C=NC3=C2N=CN=C3N)O[C@H](COP(OP(OCC(C)(C)[C@@H](O)C(NCCC(NCCSC(C)=O)=O)=O)(O)=O)(O)=O)[C@H]1OP(O)(O)=O.[Na].[Na].[Na] | ||
| 分子式 | C23H38N7O17P3S•3Na | 分子量 | 878.5 |
| 溶解度 | PBS (pH 7.2): 10 mg/ml | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.1383 mL | 5.6915 mL | 11.383 mL |
| 5 mM | 0.2277 mL | 1.1383 mL | 2.2766 mL |
| 10 mM | 0.1138 mL | 0.5692 mL | 1.1383 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet