Acetyl-DL-carnitine (chloride)
(Synonyms: (±)-Acetylcarnitine,DL-Acetylcarnitine,CAR 2:0,C2:0 Carnitine,DL-Carnitine acetyl ester) 目录号 : GC91482Acetyl-DL-carnitine is a racemic mixture of the short-chain acylcarnitine acetyl-D-carnitine and the mitochondrial metabolite acetyl-L-carnitine .
Cas No.: 2504-11-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Acetyl-DL-carnitine is a racemic mixture of the short-chain acylcarnitine acetyl-D-carnitine and the mitochondrial metabolite acetyl-L-carnitine . It increases the oxidation rate of the branched-chain 2-oxo acid 3-methyl-2-butanoate in isolated rat muscle mitochondria in the absence of carnitine when used at a concentration of 1 mM.[1] Acetyl-DL-carnitine decreases the hind limb vasculature blood flow rate in rats in a dose-dependent manner.[2] It decreases the levels of palmitic acid and oleic acid in the cerebral cortex during the recovery period in a dog model of hypoglycemic brain injury induced by insulin.[3]
References:
[1].Veerkamp, J.H., van Moerkerk, H.T.B., and Wagenmakers, A.J.M.Interaction of short-chain and branched-chain fatty acids and their carnitine and CoA esters and of various metabolites and agents with branced-chain 2-oxo acid oxidation in rat muscle and liver mitochondriaInt. J. Biochem.17(9)967-974(1985).
[2].Louis-Ferdinand, R.T., Cutroneo, K.R., Kosegarten, D.C., et al.Flow decrease through rat hind limb vasculature by (plus or minus)-carnitine, (plus or minus)-acetylcarnitine and (plus or minss)-chloroacetylcarnitine chloridesJ. Pharm. Pharmacol.22(9)704-705(1970).
[3].Benzi, G., Gorini, A., Dossena, M., et al.Recovery after hypoglycemic brain injury. Action of some biological substances on the cerebral metabolismBiochem. Pharmacol.32(6)1083-1091(1983).
| Cas No. | 2504-11-2 | SDF | Download SDF |
| 别名 | (±)-Acetylcarnitine,DL-Acetylcarnitine,CAR 2:0,C2:0 Carnitine,DL-Carnitine acetyl ester | ||
| 分子式 | C9H18NO4•Cl | 分子量 | 239.7 |
| 溶解度 | H2O : 100 mg/mL (417.19 mM; Need ultrasonic) | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.1719 mL | 20.8594 mL | 41.7188 mL |
| 5 mM | 0.8344 mL | 4.1719 mL | 8.3438 mL |
| 10 mM | 0.4172 mL | 2.0859 mL | 4.1719 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。