Acetyl Hexapeptide-38 (trifluoroacetate salt)
目录号 : GC49911
A hexapeptide
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Acetyl hexapeptide-38 is a hexapeptide that decreases IL-8 secretion in human keratinocytes when used alone or in combination with acetyl pentapeptide-46.1 Formulations containing acetyl hexapeptide-38 have been used to diminish the appearance of skin aging.
1.Tittl, J., and Wolf, C.Compositions and methods for mitigating skin irritation and enhancing skin barrier function(2016)
| Cas No. | SDF | Download SDF | |
| Canonical SMILES | O=C([C@H](CO)NC(C)=O)N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](C(C)C)C(N[C@@H](CCCNC(N)=N)C(N[C@@]([H])([C@@H](C)O)C(N)=O)=O)=O)=O)=O.OC(C(F)(F)F)=O | ||
| 分子式 | C30H56N10O9 • XCF3COOH | 分子量 | 700.8 |
| 溶解度 | DMF: Slightly soluble,DMSO: Slightly soluble,PBS (pH 7.2): 0.5 mg/mL | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.4269 mL | 7.1347 mL | 14.2694 mL |
| 5 mM | 0.2854 mL | 1.4269 mL | 2.8539 mL |
| 10 mM | 0.1427 mL | 0.7135 mL | 1.4269 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
The reaction of D-glucose with aminoguanidine
Carbohydr Res 1995 Feb 1;267(1):17-25.PMID:7697666DOI:10.1016/0008-6215(94)00285-n.
The reaction of D-glucose with aminoguanidine was examined at pH 7.0 and 37 degrees C (phosphate buffer). Under these conditions, the reaction requires ca. 42 days for 50% of the sugar to react, as measured by the disappearance of D-glucose, and at 60 degrees C all the aminoguanidine had reacted within 72 h. The initial product, a beta-D-glucopyranosyl aminoguanidine (1) was obtained in the crystalline state as the trifluoroacetate salt. Data collected on this compound suggests that, in solution, it is largely a glycosylamine in the beta pyranose form. Acetylation gave a crystalline heptaacetate (2), which, in solution (as evidenced by NMR spectroscopy) exists in two different conformational forms. The crystal structure of the heptaacetate also includes two conformers. Both crystallographically independent molecules are in the normal beta pyranose form, with the acetylated guanyl residue occupying different spatial positions relative to the ring.
Synthesis, properties, and reactions of alpha- and beta-D-glucopyranosyl esters of some tripeptides
Carbohydr Res 1980 Jun;82(1):31-43.PMID:6772301DOI:10.1016/s0008-6215(00)85517-2.
The 2,3,4,6-tetra-O-benzyl-1-O-(N-benzyloxycarbonyltripeptidyl)-D-glucopyranoses ), 8, and 13 were synthesised from 2,3,4,6-tetra-O-benzyl-alpha-D-glucopyranose and the active esters of the appropriate N-protected tripeptides (Gly-Cly-Gly-, L-Phe-Gly-Gly-, and Gly-Gly-L-Phe-) in the presence of imidazole; the anomeric mixtures were resolved and the alpha and beta anomers characterised. The beta anomer of 13, containing the L and D enantiomers (ratio approximately 3:1) of Gly-Gly-Phe- as the aglycon, could be resolved by column chromatography into the pure isomeric forms. Catalytic hydrogenolysis of the beta anomers, in the presence and absence of a strong acid, yielded the free 1-esters 2 beta, 9 beta, and 14 beta, which were characterised as the monoxalate or trifluoroacetate salts and as free bases. Similarly, the alpha anomers afforded 2 alpha, 9 alpha, and 14 alpha, whereas omission of the strong acid led to accompanying 1 leads to 2 acyl migration, to give the 2-O-acyl derivatives. All of the compounds prepared were converted into the N-acetyl and/or peracetylated derivatives. The 1-esters 2 beta and 9 beta, both in the charged and uncharged form, and the trifluoroacetate salt of 14 beta, are susceptible to cleavage by beta-D-glucosidase; the enzyme had no effect on the uncharged form of 14 beta. This difference between 14 beta and its salt is discussed in conformational terms.