Acetyl-L-carnitine-d3 (chloride)
(Synonyms: O-Acetyl-L-carnitine-d3-1 hydrochloride) 目录号 : GC46789
An internal standard for the quantification of L-acetylcarnitine
Cas No.:362049-62-5
Sample solution is provided at 25 µL, 10mM.
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Acetyl-L-carnitine-d3 is intended for use as an internal standard for the quantification of L-acetylcarnitine by GC- or LC-MS. Acetyl-L-carnitine is an acetylated form of the essential mitochondrial metabolite L-carnitine that is catabolized by plasma esterases into carnitine.1,2,3 Acetyl-L-carnitine facilitates the uptake of acetyl-CoA into mitochondria during fatty acid oxidation, enhances acetylcholine production, and stimulates protein and membrane phospholipid synthesis. In vivo, acetyl-L-carnitine (100 mg/kg) increases mGlu2/3 receptor protein levels and mechanical pain thresholds in a mouse model of chronic inflammatory pain induced by complete Freund's adjuvant.4
1.Vaz, F.M., and Wanders, R.J.A.Carnitine biosynthesis in mammalsBiochem. J.361(Pt 3)417-429(2002) 2.Fu, L., Huang, M., and Chen, S.Primary carnitine deficiency and cardiomyopathyKorean. Circ. J.43(12)785-792(2013) 3.Stieger, B., O'Neill, B., and KrÄhenbÜhl, S.Characterization of L-carnitine transport by rat kidney brush-border-membrane vesiclesBiochemistry Journal309(Pt 2)643-647(1995) 4.Notartomaso, S., Mascio, G., Bernabucci, M., et al.Analgesia induced by the epigenetic drug, L-acetylcarnitine, outlasts the end of treatment in mouse models of chronic inflammatory and neuropathic painMol. Pain13:1744806917697009(2017)
| Cas No. | 362049-62-5 | SDF | |
| 别名 | O-Acetyl-L-carnitine-d3-1 hydrochloride | ||
| Canonical SMILES | OC(C[C@@H](OC(C([2H])([2H])[2H])=O)C[N+](C)(C)C)=O.[Cl-] | ||
| 分子式 | C9H15D3NO4.Cl | 分子量 | 242.7 |
| 溶解度 | H2O : 250 mg/mL (1029.99 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 4.1203 mL | 20.6016 mL | 41.2031 mL |
| 5 mM | 0.8241 mL | 4.1203 mL | 8.2406 mL |
| 10 mM | 0.412 mL | 2.0602 mL | 4.1203 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet