Acetylatractylodinol
(Synonyms: 乙酰基仓术呋喃烃醇,Tractylodinol acetate) 目录号 : GC60557
Acetylatractylodinol可从Atractylodeslancea中分离得到，具有抗氧化活性。
Cas No.:61582-39-6
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Acetylatractylodinol, isolated from Atractylodes lancea, possesses antioxidant activity[1].
[1]. Heilmann, JÖrg, et al. Antioxidant activity of constituents from Atractylodes lancea.
| Cas No. | 61582-39-6 | SDF | |
| 别名 | 乙酰基仓术呋喃烃醇,Tractylodinol acetate | ||
| Canonical SMILES | CC(OC/C=C/C#CC#C/C=C/C1=CC=CO1)=O | ||
| 分子式 | C15H12O3 | 分子量 | 240.25 |
| 溶解度 | 储存条件 | Store at -20°C | |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 4.1623 mL | 20.8117 mL | 41.6233 mL |
| 5 mM | 0.8325 mL | 4.1623 mL | 8.3247 mL |
| 10 mM | 0.4162 mL | 2.0812 mL | 4.1623 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Effect of the rhizomes of Atractylodes lancea and its constituents on the delay of gastric emptying
J Ethnopharmacol 2003 Jan;84(1):51-5.PMID:12499077DOI:10.1016/s0378-8741(02)00260-x.
The effect of rhizomes of Atractylodes lancea on gastric disorders, in particular, the delay in gastric emptying induced by N(G)-nitro-L-arginine in rats, was investigated. Intragastric treatment with an aqueous extract (250 mg/kg) and its lipophilic fractions (4 mg/kg) significantly improved delayed gastric emptying. The major constituents of the lipophilic fraction were two sesquiterpens, hinesol and beta-eudesmol, and four known polyacetylenic compounds, atractylodin, atractylodinol, Acetylatractylodinol and 4,6,12-tetradecatriene-8,10-diyne-1,3,14-triol. The activity was found in the four polyacetylenic compounds at a similar potency, but not in the two sesquiterpens. To clarify the effect of the four polyacetylenic compounds in this extract, we attempted to evaluate the activity of atractylodin, as representative, at a dose of 0.2 mg/kg based on the total amounts (0.2 mg/250 mg aqueous extract) of the four polyacetylenic compounds. In addition, atractylodin improved the delay in gastric emptying at between 0.1 and 0.3 mg/kg in a dose-dependent manner. These results suggest that the aqueous extract improved the delayed gastric emptying, and polyacetylenic compounds contributed to its activity.
[Studies on chemical constituents in roots of Peucedanum praeruptorum]
Zhongguo Zhong Yao Za Zhi 2005 May;30(9):675-7.PMID:16075731doi
Objective: To study the chemical constituents in roots of Peucedanum praeruptorum. Method: The constituents were isolated by column chromatography on silica gel and ODS, and identified by MS spectroscopic methods including NMR and. Result: Seven compounds, Acetylatractylodinol (I), tanshinone II A (II), tanshinone I (III), cis-3', 4'-diisovalerylkhellactone(IV), cis-3',4'-disenecioylkhellactone(V), (+)praeruptorin B(VI), and beta-sitosterol(V), were isolated and identified. Conclusion: Compounds I, II, III, IV were isolated from this plant for the first time.