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Acloproxalap

目录号 : GC68613

Acloproxalap 是一种基于喹啉的醛清除剂,可用于有毒醛积累的疾病研究,如眼部、皮肤等炎症性疾病,肺炎等呼吸系统疾病,器官疾病以及病毒感染相关性综合症等。

Acloproxalap Chemical Structure

Cas No.:1824609-67-7

规格 价格 库存 购买数量
5mg
¥720.00
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10mg
¥1,170.00
现货
25mg
¥2,385.00
现货
50mg
¥3,825.00
现货
100mg
¥6,120.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

Quality Control & SDS

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产品描述

Acloproxalap is a quinoline-based aldede scavenger that can be used in studies of diseases with toxic aldede accumulation, such as inflammatory diseases of the eye and skin, respiratory diseases such as pneumonia, organ diseases, and viral infection-related syndromes[1][2].

Acloproxalap (compound I-6) (100 or 200 mg/kg, i.p. or p.o., everyday, 6 days) can effectively improve inflammation of the colon in acute ulcerative colitis (UC) female Swiss Webster mice[1].

Animal Model: Acute ulcerative colitis (UC) in female Swiss Webster mice[1]
Dosage: 100 mg/kg, 200 mg/kg
Administration: Intraperitoneal injection for 100 mg/kg, oral gavage for 200 mg/kg; everyday; 6 days
Result: Inhibited weight loss in intraperitoneal injection mice significantly while there was no significant difference in the oral gavage group compared to the control group.
Both significantly reduced colonic histopathological parameters.
Animal Model: Male non-naÏve beagle dogs[2]
Dosage: 3 mg/kg
Administration: Intravenous injection; once
Result: The pharmacokinetic parameters of Acloproxalap (compound I-1)
Parameter Acloproxalap (compound I-1)
t1/21.82 h
Tmax0.518 h
Clearance12.2 mL/kg/min
steady-state volume1385 mL/kg
AUC0-t4103 ng/mL*h
AUC0?inf_obs4137 ng/mL*h
Animal Model: Male non-naÏve beagle dogs[2]
Dosage: 10 mg/kg
Administration: Oral gavage; once
Result: The pharmacokinetic parameters of Acloproxalap (compound I-1)
Parameter Acloproxalap (compound I-1)
t1/23.02 h
Tmax0.518 h
Cmax3558 ng/mL
AUC0-t9361 ng/mL*h
AUC0?inf_obs9546 ng/mL*h
BioA75%

[1]. Susan Macdonald, et al. Treatment of inflammatory disorders. US20190105322
[2]. Todd Brady, et al. Pharmaceutical formulations and uses thereof. WO2021231792

Chemical Properties

Cas No. 1824609-67-7 SDF Download SDF
分子式 C12H14N2O 分子量 202.25
溶解度 DMSO : 100 mg/mL (494.44 mM; Need ultrasonic) 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.9444 mL 24.7219 mL 49.4438 mL
5 mM 0.9889 mL 4.9444 mL 9.8888 mL
10 mM 0.4944 mL 2.4722 mL 4.9444 mL
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