ACTH (11-24) (human, mouse, rat, porcine, bovine, ovine) (acetate)
(Synonyms: α11-24-ACTH; Adrenocorticotropic Hormone (11-24); Corticotropin (11-24)) 目录号 : GC92106ACTH (11-24) (human, mouse, rat, porcine, bovine, ovine) (acetate)是ACTH的肽片段，ACTH是一种在大脑中发现的肽激素，参与生物应激反应，是MC2R的拮抗剂。
Sample solution is provided at 25 µL, 10mM.
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Adrenocorticotropic hormone (ACTH) (11-24) is a peptide fragment of ACTH, a peptide hormone found in the brain that is involved in the biological stress response, and an antagonist of melanocortin receptor 2 (MC2R), also known as the ACTH receptor (IC50 = ~1 nM in HeLa cells expressing the mouse receptor).1,2 It induces corticosterone and aldosterone production in isolated rat zona glomerulosa and zona fasciculata cells, respectively, with minimum effective concentrations of 4 and 3 ?M, respectively.3 Unlike ACTH (4-11), ACTH (11-24) does not induce differentiation of primary mouse melanocytes.4 In vivo, ACTH (11-24) (1.69 ?g/animal, i.c.v.) inhibits ACTH-induced stretching, yawning, and penile erections in rats.5
References:
[1]. Strand, F.L., Lee, S.J., Zuccarelli, L.A., et al.Non-corticotropic ACTH peptides modulate nerve development and regenerationRev. Neurosci.4(4)321-363(1993).
[2]. Kapas, S., Cammas, F.M., Hinson, J.P., et al.Agonist and receptor binding properties of adrenocorticotropin peptides using the cloned mouse adrenocorticotropin receptor expressed in a stably transfected HeLa cell lineEndocrinology137(8)3291-3294(1996).
[3]. Szalay, K.S., De Wied, D., and Stark, E.Effects of ACTH-(11-24) on the corticosteroid production of isolated adrenocortical cellsJ. Steroid Biochem.32(2)259-262(1989).
[4]. Hirobe, T., and Hiroyuki, A.ACTH4-12 is the minimal message sequence required to induce the differentiation of mouse epidermal melanocytes in serum-free primary cultureJ. Exp. Zool.286(6)632-640(2000).
[5]. Genedani, S., and Bernardi, M.ACTH-(11-24) antagonizes ACTH-(1-24)-induced behavioral syndromeNeuropeptides26(4)241-244(1994).
| Cas No. | SDF | ||
| 别名 | α11-24-ACTH; Adrenocorticotropic Hormone (11-24); Corticotropin (11-24) | ||
| 化学名 | α11-24-corticotropin, acetate | ||
| Canonical SMILES | O=C(N1CCC[C@H]1C(N[C@@H](C(C)C)C(NCC(N[C@@H](CCCCN[H])C(N[C@@H](CCCCN[H])C(N[C@@H](CCC/N=C(N[H])/N)C(N[C@@H](CCC/N=C(N[H])/N)C(N2CCC[C@H]2C(N[C@@H](C(C)C)C(N[C@@H](CCCCN[H])C(N[C@@H](C(C)C)C(N[C@@H](CC3=CC=C(O[H])C=C3)C(N4CCC[C@H]4C(O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)=O)[C@H](CCCCN[H])N[H].CC(O)=O | ||
| 分子式 | C77H134N24O16 ? XC2H4O2 | 分子量 | 1652 |
| 溶解度 | DMSO: Slightly soluble: 0.1-1 mg/ml,PBS (pH 7.2): Soluble: ≥10 mg/ml | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.6053 mL | 3.0266 mL | 6.0533 mL |
| 5 mM | 0.1211 mL | 0.6053 mL | 1.2107 mL |
| 10 mM | 0.0605 mL | 0.3027 mL | 0.6053 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet