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Actinonin Sale

(Synonyms: 放线酰胺素,(-)-Actinonin,Ro 06-1467) 目录号 : GC16350

An aminopeptidase inhibitor

Actinonin Chemical Structure

Cas No.:13434-13-4

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5mg
¥1,020.00
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25mg
¥3,875.00
现货

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Sample solution is provided at 25 µL, 10mM.

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产品描述

Actinonin is a peptidomimetic antibiotic produced by Actinomyces that inhibits aminopeptidases. It inhibits the following matrix metalloproteinases (MMPs): MMP-1 (Ki = 300 nM), MMP-3 (Ki = 1,700 nM), MMP-8 (Ki = 130 nM), and MMP-9 (Ki = 330 nM).[1] Actinonin acts as an herbicide by targeting plastid peptide deformylase, an enzyme required for N-terminal processing of plastid-encoded proteins.[2] Actinonin has also been identified as an effective inhibitor of human meprin α (Ki = 20 nM), a zinc endopeptidase that cleaves matrix proteins.[3] More recently actinonin has been shown to inhibit tumor cell invasion and matrix degradation and to induce apoptosis in animal models by targeting human mitochondrial peptide deformylase.[4]

Reference:
[1]. Wahl, R.C., Pulvino, T.A., Mathiowetz, A.M., et al. Hydroxamate inhibitors of human gelatinase B (92 kDa). Bioorganic & Medicinal Chemistry Letters 5(4), 349-352 (1995).
[2]. Duke, S.O., and Dayan, F.E. Modes of action of microbially-produced phytotoxins. Toxins (Basel) 3(8), 1038-1064 (2011).
[3]. Kruse, M.N., Becker, C., Lottaz, D., et al. Human meprin α and β homo-oligomers: Cleavage of basement membrane proteins and sensitivity to metalloprotease inhibitors. Biochemistry Journal 378(1), 383-389 (2004).
[4]. Lee, M.D., She, Y., Soskis, M.J., et al. Human mitochondrial peptide deformylase, a new anticancer target of actinonin-based antibiotics. Journal of Clinical Investigation 114(8), 1107-1116 (2004).

Chemical Properties

Cas No. 13434-13-4 SDF
别名 放线酰胺素,(-)-Actinonin,Ro 06-1467
化学名 (2R)-N4-hydroxy-N1-[(1S)-1-[[(2S)-2-(hydroxymethyl)-1-pyrrolidinyl]carbonyl]-2-methylpropyl]-2-pentyl-butanediamide
Canonical SMILES O=C([C@H](C(C)C)NC([C@H](CCCCC)CC(NO)=O)=O)N1CCC[C@H]1CO
分子式 C19H35N3O5 分子量 385.5
溶解度 30mg/ml in ethanol;30mg/ml in DMSO;30mg/ml in dimethyl formamide 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
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1 mg 5 mg 10 mg
1 mM 2.594 mL 12.9702 mL 25.9403 mL
5 mM 0.5188 mL 2.594 mL 5.1881 mL
10 mM 0.2594 mL 1.297 mL 2.594 mL
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