Actinotetraose Hexatiglate
(Synonyms: Tigloside) 目录号 : GC42714
A unique tetrasaccharide
Cas No.:216590-44-2
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Actinotetraose hexatiglate is a unique tetrasaccharide with six tiglate esters that was isolated from an Amycolatopsis culture. The sugar is distinguished by a two-fold axis of symmetry and is a co-metabolite of quinaldopeptin, a cytotoxic antibiotic with anthelmintic activity. The biological role of this metabolite is not known but is suspected to lack antimicrobial activity.
| Cas No. | 216590-44-2 | SDF | |
| 别名 | Tigloside | ||
| Canonical SMILES | O[C@H]1[C@H](O)[C@@H](COC(/C(C)=C/C)=O)O[C@H](O[C@]2([H])[C@H](O[C@]3([H])O[C@H](CO)[C@@H](OC(/C(C)=C/C)=O)[C@H](OC(/C(C)=C/C)=O)[C@H]3O)[C@@H](O)[C@H](O)[C@@H](COC(/C(C)=C/C)=O)O2)[C@@H]1O[C@@]4([H])[C@H](O)[C@@H](OC(/C(C)=C/C)=O)[C@H](OC(/C(C)=C/C) | ||
| 分子式 | C54H78O27 | 分子量 | 1159.2 |
| 溶解度 | Soluble in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 0.8627 mL | 4.3133 mL | 8.6266 mL |
| 5 mM | 0.1725 mL | 0.8627 mL | 1.7253 mL |
| 10 mM | 0.0863 mL | 0.4313 mL | 0.8627 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Structure of Actinotetraose Hexatiglate, a unique glucotetraose from an actinomycete bacterium
J Antibiot (Tokyo) 1998 Dec;51(12):1093-8.PMID:10048568DOI:10.7164/antibiotics.51.1093.
An Actinomycete strain A499 belonging to the genera Amycolatopsis or Amycolata isolated from a Western Australian soil sample produced the cyclic decapeptide antibiotic quinaldopeptin (1), together with the Actinotetraose Hexatiglate (2), the hexa-ester of a novel non-reducing glucotetraose.
Actinotetraoses I-K: tetrasaccharide metabolites produced by an insect-derived actinobacteria, Amycolatopsis sp. HCa1
Chem Biodivers 2013 Feb;10(2):296-302.PMID:23418177DOI:10.1002/cbdv.201200224.
An isolate of rare actinobacteria strain Amycolatopsis sp. HCa1 obtained from the gut of grasshopper produced seven different metabolites in vitro. The metabolites isolated from its mycelia cakes were characterized by NMR and MS analyses. Actinotetraose Hexatiglate (or tigloside; 1) with nonreducing glucotetraose skeleton was isolated as a major constituent; three new tetrasaccharide derivatives actinotetraoses I-K (2-4, resp.) and three known actinotetraoses A-C (5-7, resp.) were also isolated.