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Acyclovir-d4 Sale

(Synonyms: 阿昔洛韦D4,Aciclovir-d4; Acycloguanosine-d4) 目录号 : GC46797

An internal standard for the quantification of acyclovir

Acyclovir-d4 Chemical Structure

Cas No.:1185179-33-2

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1 mg
¥3,751.00
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Sample solution is provided at 25 µL, 10mM.

Description

Acyclovir-d4 is intended for use as an internal standard for the quantification of acyclovir by GC- or LC-MS. Acyclovir is a guanosine analog that has antiviral activity in vitro against the herpes simplex viruses, varicella zoster virus, Epstein-Barr virus, cytomegalovirus, and human herpes virus 6 (ID50s = 0.1-63.1 μM).1 It diffuses freely into cells and is selectively converted into acyclo-guanosine monophosphate by a virus-specific thymidine kinase. During DNA replication, the phosphorylated form of acyclovir is preferentially incorporated into viral DNA, resulting in premature chain termination and inhibition of further DNA polymerase activity.2 Acyclovir (5 mg/kg) reduces viral titers in mice infected with the herpes simplex virus-1 (HSV-1) strain SC16.3

1.Balfour, H.H., Jr.Management of cytomegalovirus disease with antiviral drugsRev.Infect.Dis.12(Suppl. 7)S849-S860(1990) 2.Bean, B.Antiviral therapy: Current concepts and practicesClin.Microbiol.Rev.5(2)146-182(1992) 3.Ashton, R.J., Abbott, K.H., Smith, G.M., et al.Antiviral activity of famciclovir and acyclovir in mice infected intraperitoneally with herpes simplex virus type 1 SC16J. Antimicrob. Chemother.34(2)287-290(1994)

化学性质

Cas No. 1185179-33-2 SDF
别名 阿昔洛韦D4,Aciclovir-d4; Acycloguanosine-d4
Canonical SMILES O=C1C2=C(N(COC([2H])([2H])C([2H])([2H])O)C=N2)N=C(N)N1
分子式 C8H7D4N5O3 分子量 229.2
溶解度 DMSO: Soluble 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.363 mL 21.815 mL 43.63 mL
5 mM 0.8726 mL 4.363 mL 8.726 mL
10 mM 0.4363 mL 2.1815 mL 4.363 mL
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