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Adapalene-d3 Sale

(Synonyms: 阿达帕林 d3) 目录号 : GC46798

An internal standard for the quantification of adapalene

Adapalene-d3 Chemical Structure

Cas No.:1276433-89-6

规格 价格 库存 购买数量
500 μg
¥2,141.00
现货
1 mg
¥4,078.00
现货

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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Adapalene-d3 is intended for use as an internal standard for the quantification of adapalene by GC- or LC-MS. Adapalene is a synthetic retinoid and an agonist of retinoic acid receptors (RARs; Kds = 1,100, 34, and 130 nM for RARα, RARβ, and RARγ, respectively).1,2,3,4,5 It inhibits growth and differentiation of sebocytes in a concentration-dependent manner in primary rat preputial cell culture. Adapalene (10 μM) completely inhibits the activity of soybean 15-lipoxygenase (15-LOX) in an enzyme assay and inhibits the 5- and 15-LOX pathways in human blood polymorphonuclear leukocytes (PMNs).2 It reduces the protein levels of toll-like receptor 2 (TLR2) and IL-10 in skin explants isolated from patients with acne and healthy controls in a concentration-dependent manner but increases the expression of the antigen-presenting protein CD1d in acne skin explants while decreasing it in control explants.3 It inhibits inflammation in rodent models of ear edema induced by arachidonic acid and carrageenan-induced paw edema.2 Adapalene (100 μM) also induces apoptosis and inhibits proliferation of CC-531, HT-29, and LoVo colon cancer cells and reduces tumor growth in a DLD-1 colon cancer nude mouse xenograft model in a dose-dependent manner.5,4 Formulations containing adapalene have been used in the treatment of acne vulgaris.

1.Kim, M.J., Ciletti, N., Michel, S., et al.The role of specific retinoid receptors in sebocyte growth and differentiation in cultureJournal of Investigative Dermatology114349-353(2000) 2.Hensby, C., Cavey, D., Bouclier, M., et al.The in vivo and in vitro anti-inflammatory activity of CD271: A new retinoid-like modulator of cell differentiationAgents Actions29(1-2)56-58(1990) 3.Tenaud, I., Khammari, A., and Dreno, B.In vitro modulation of TLR-2, CD1d and IL-10 by adapalene on normal human skin and acne inflammatory lesionsExp. Dermatol.16(6)500-506(2007) 4.Ocker, M., Herold, C., Ganslmayer, M., et al.The synthetic retinoid adapalene inhibits proliferation and induces apoptosis in colorectal cancer cells in vitroInt. J. Cancer107(3)453-459(2003) 5.Shi, X.-N., Li, H., Yao, H., et al.Adapalene inhibits the activity of cyclin-dependent kinase 2 in colorectal carcinomaMol. Med. Rep.12(5)6501-6508(2015)

Chemical Properties

Cas No. 1276433-89-6 SDF
别名 阿达帕林 d3
Canonical SMILES [2H]C([2H])([2H])OC1=C(C2(C[C@H](C3)C4)C[C@H]4C[C@H]3C2)C=C(C=C1)C(C=C5)=CC6=C5C=C(C(O)=O)C=C6
分子式 C28H25D3O3 分子量 415.5
溶解度 DMF: 5 mg/ml,DMSO: 5 mg/ml 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mM 2.4067 mL 12.0337 mL 24.0674 mL
5 mM 0.4813 mL 2.4067 mL 4.8135 mL
10 mM 0.2407 mL 1.2034 mL 2.4067 mL
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