ADRA1D receptor antagonist 1
目录号 : GC68627ADRA1D receptor antagonist 1 是一个高效、选择性的，有口服活性的 α1D 肾上腺素受拮抗剂，Ki 值为 1.6 nM。
Cas No.:1191908-14-1
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
ADRA1D receptor antagonist 1 is a potent, selective and orally active α1D adrenoceptor antagonist, with a Ki of 1.6 nM[1].
ADRA1D receptor antagonist 1 shows low hERG inhibition[1].
ADRA1D receptor antagonist 1 exhibits higher selectivity for α1D-AR over α1A- and α1B-ARs [1].
ADRA1D receptor antagonist 1 (4.4 µg/kg; i.v.) dose-dependently decreases the non-voiding bladder contractions during the urinary storage phase in rats with BOO[1].
| Animal Model: | Rat with bladder outlet obstruction (BOO)[1] |
| Dosage: | 4.4 µg/kg |
| Administration: | Intravenous injection |
| Result: | Dose-dependently decreased the non-voiding bladder contractions during urinary storage phase in rats with BOO. |
[1]. Sakauchi N, et al. Discovery of 5-Chloro-1-(5-chloro-2-(metlsulfonyl)benzyl)-2-imino-1,2-didropyridine-3-carboxamide (TAK-259) as a Novel, Selective, and Orally Active α1D Adrenoceptor Antagonist with Antiurinary Frequency Effects: Reducing Human Ethe
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.9656 mL | 14.828 mL | 29.656 mL |
| 5 mM | 0.5931 mL | 2.9656 mL | 5.9312 mL |
| 10 mM | 0.2966 mL | 1.4828 mL | 2.9656 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。