Adrenorphin (human, mouse, rat, bovine) (trifluoroacetate salt)
(Synonyms: Met5-Enkephalin-Arg6-Arg7-Val8-NH2, Metorphamide, Tyr-Gly-Gly-Phe-Met-Arg-Arg-Val-NH2) 目录号 : GC90487一种μ-阿片受体的八肽激动剂。
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Adrenorphin is an octapeptide agonist of μ-opioid receptors that is involved in nociception.1,2 It is a C-terminally amidated cleavage product corresponding to amino acids 210-218 of human proenkephalin A. It was originally found in a human pheochromocytoma but has also been found in the rat adrenal medulla and the rat olfactory bulb, pothalamus, and striatum, among other brain regions.1,3,4 Adrenorphin selectively binds to μ-opioid receptors over κ- and δ-opioid receptors (Kis = 0.12, 0.248, and 2.65 nM, respectively, in a radioligand binding assay).1 Intracerebroventricular administration of adrenorphin (6.1 nmol/animal) increases the latency to paw licking in the hot plate test in mice, indicating analgesic activity, an effect that can be reduced by the non-selective opioid receptor antagonist naloxone.2 It also induces respiratory depression in mice and rabbits (ED50s = 6 and 71.1 nmol/animal, respectively).
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 1.0503 mL | 5.2515 mL | 10.5031 mL |
| 5 mM | 0.2101 mL | 1.0503 mL | 2.1006 mL |
| 10 mM | 0.105 mL | 0.5252 mL | 1.0503 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。