AH 11110 hydrochloride
目录号 : GC10197
α1B-AR ligand,subtype-selective
Cas No.:179388-65-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
AH 11110 hydrochloride is a selective antagonist of α1B-adrenoceptor [1].
α1B-adrenoceptor (α1B-AR) belongs to α1- adrenergic receptors, which include three subtypes α1A, α1B and α1D and play an important role in regulating cell growth and proliferation.
AH 11110 hydrochloride is a selective α1B-AR antagonist. AH11110A inhibited cloned α1B-AR with Ki value of 79.4 nM and exhibited 32- and 26-fold selectivity over α1A- and α1D-ARs, respectively [1]. In rat vas deferens and rat perfused kidney, AH11110A exhibited affinities for α1A-AR, α1B-AR and α1D-AR with pA2 values of 6.41, 5.40-6.54 and 5.47-5.48, respectively. Also, AH11110A displayed affinity for α2-adrenoceptor in rabbit vas deferens with pA2 value of 5.44. In ligand binding studies, AH11110A exhibited affinities for native and cloned α1B-AR with pKi of 7.10-7.73. AH11110A increased contraction of rat vas deferens [2]. In isolated spleen strips from guinea-pig, AH11110A competitively antagonized tissue contraction induced by noradrenaline in a concentration-dependent way [2].
References:
[1]. Erami C, Zhang H, Ho JG, et al. Alpha(1)-adrenoceptor stimulation directly induces growth of vascular wall in vivo. Am J Physiol Heart Circ Physiol, 2002, 283(4): H1577-1587.
[2]. Eltze M, König H, Ullrich B, et al. Failure of AH11110A to functionally discriminate between alpha(1)-adrenoceptor subtypes A, B and D or between alpha(1)- and alpha(2)-adrenoceptors. Eur J Pharmacol, 2001, 415(2-3): 265-276.
| Cas No. | 179388-65-9 | SDF | |
| 化学名 | (S)-1-([1,1'-biphenyl]-2-yloxy)-4-imino-4-(piperidin-1-yl)butan-2-ol hydrochloride | ||
| Canonical SMILES | O[C@H](COC1=CC=CC=C1C2=CC=CC=C2)CC(N3CCCCC3)=N.Cl | ||
| 分子式 | C21H26N2O2.HCl | 分子量 | 374.91 |
| 溶解度 | Soluble to 25 mM in Water | 储存条件 | Store at RT |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 2.6673 mL | 13.3365 mL | 26.6731 mL |
| 5 mM | 0.5335 mL | 2.6673 mL | 5.3346 mL |
| 10 mM | 0.2667 mL | 1.3337 mL | 2.6673 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。