AKR1D1 Human
目录号 : GP21381Aldo-Keto Reductase Family 1 Member D1 Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 95.0% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | 3-oxo-5-beta-steroid 4-dehydrogenase; Aldo-Keto ReductaseFamily 1; Member D1; SRD5B1; Delta(4)-3-Ketosteroid 5-Beta-Reductase; Delta4-3-Ketosteroid-5-Beta-Reductase; Delta(4)-3-Oxosteroid 5-Beta-Reductase; CBAS2;Steroid-5-Beta-Reductase; Beta Polypeptide 1 (3-Oxo-5 Beta-Steroid Delta4-Dehydrogenase Beta 1); Aldo-Keto Reductase Family 1; Member D1 (Delta4-3-Ketosteroid-5-Beta-Reductase); Aldo-Keto Reductase Family 1 Member D1; 3-Oxo-5-Beta-Steroid4-Dehydrogenase; EC 1.3.1.3; 3o5bred. | ||
| Amino Acid Sequence | MDLSAASHRI PLSDGNSIPI IGLGTYSEPK STPKGACATS VKVAIDTGYRHIDGAYIYQN EHEVGEAIRE KIAEGKVRRE DIFYCGKLWA TNHVPEMVRP TLERTLRVLQ LDYVDLYIIEVPMAFKPGDE IYPRDENGKW LYHKSNLCAT WEAMEACKDA GLVKSLGVSN FNRRQLELILNKPGLKHKPV SNQVECHPYFTQPKLLKFCQ QHDIVITAYS PLGTSRNPIW VNVSSPPLLK DALLNSLGKR YNKTAAQIVL RFNIQRGVVV IPKSFNLERIKENFQIFDFS LTEEEMKDIE ALNKNVRFVE LLMWRDHPEY PFHDEY. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | The AKR1D1 protein solution (1mg/ml) contains 20mMTris-HCl buffer (pH 8.5), 1mM DTT, 0.1M NaCl and 10% glycerol. | ||
Aldo-keto reductase family 1 member D1 (AKR1D1) belongs to the AKR superfamily. The AKR family proteins are soluble NADPH oxidoreductases, which have vital roles in the metabolism of drugs, carcinogens and reactive aldehydes. AKR1D1 is also responsible for the catalysis of the 5-beta-reduction of bile acid intermediates and steroid hormones that carry a delta (4)-3-1 structure. AKR1D1 is highly expressed in the liver, colon and testis. Deficiency of the AKR1D1 enzyme may contribute to hepatic dysfunction.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.