AKT1 Human
目录号 : GP22419Protein Kinase B Alpha Human Recombinant
Sample solution is provided at 25 µL, 10mM.
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| Purity | Greater than 85% as determined by SDS-PAGE. | Source | Escherichia Coli. |
| Phycical Appearance | Sterile filtered colorless solution. | Shipping Condition | Shipped with Ice Packs. |
| Synonyms | V-Akt Murine Thymoma Viral Oncogene Homolog 1; ProteinKinase B Alpha; Proto-Oncogene C-Akt; RAC-PK-Alpha; EC 2.7.11.1; PKB Alpha; CWS6;PKB; RAC; RAC-Alpha Serine/Threonine-Protein Kinase; Rac Protein Kinase Alpha;Protein Kinase B; PKB-ALPHA; RAC-ALPHA; EC 2.7.11; AKT1m; PRKBA; AKT; RAC-alphaserine/threonine-protein kinase. | ||
| Amino Acid Sequence | MGSSHHHHHH SSGLVPRGSH MGSMSDVAIV KEGWLHKRGE YIKTWRPRYF LLKNDGTFIG YKERPQDVDQREAPLNNFSV AQCQLMKTER PRPNTFIIRC LQWTTVIERT FHVETPEERE EWTTAIQTVA DGLKKQEEEEMDFRSGSPSD NSGAEEMEVS LAKPKHRVTM NEFEYLKLLGKGTFGKVILV KEKATGRYYA MKILKKEVIV AKDEVAHTLT ENRVLQNSRHPFLTALKYSF QTHDRLCFVM EYANGGELFF HLSRERVFSE DRARFYGAEI VSALDYLHSE KNVVYRDLKLENLMLDKDGH IKITDFGLCK EGIKDGATMK TFCGTPEYLA PEVLEDNDYG RAVDWWGLGVVMYEMMCGRL PFYNQDHEKL FELILMEEIR FPRTLGPEAK SLLSGLLKKDPKQRLGGGSE DAKEIMQHRF FAGIVWQHVY EKKLSPPFKP QVTSETDTRY FDEEFTAQMI TITPPDQDDSMECVDSERRP HFPQFSYSAS GTA. | ||
| Stability | Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles. | ||
| Formulation | AKT1protein solution (0.5mg/ml) containing 20mM Tris-HCl (pH8.0) and 10% glycerol. | ||
Akt1, also known as Akt or else protein kinase B (PKB) is an importantmolecule in mammaliancellular signaling. In humans, there are three genes inthe "Akt family": Akt1, Akt2, and Akt3. Moreover, these enzymes aremembers of the serine/threonine-specific protein kinase family (EC2.7.11.1). Akt1is involved in cellular survival pathways, by inhibiting apoptoticprocesses.Akt1 is also able to induce protein synthesis pathways, and is therefore a keysignaling protein in the cellular pathways which lead to skeletal musclehypertrophy, and general tissue growth. Since it can block apoptosis, andthereby promote cell survival, Akt1 has been implicated as a most importantfactor in numerous types of cancer. Akt (now also called Akt1) was at firstidentified as the oncogenein the transforming retrovirus, AKT8.
Store at 4°C if entire vial will be used within 2-4 weeks. Store, frozen at -20°C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Avoid multiple freeze-thaw cycles.