Albendazole-d7

Albendazole-d₇ is intended for use as an internal standard for the quantification of albendazole by GC- or LC-MS. Albendazole is an orally bioavailable benzimidazole anthelmintic that is active against a variety of helminths, including liver flukes, tapeworms, and roundworms.¹ It eliminates Trichostrongylus in the fourth stomach of cattle and sheep when orally administered at doses ranging from 2.5 to 10 mg/kg as well as other species in the fourth stomach and the small and large intestine. Albendazole (0.05% in the diet) protects mice against lethal infection with A. suum larvae. It also inhibits growth of HT-29 human colorectal cancer cells (IC₅₀ = 0.12 µM), halts the cell cycle at the G₂/M phase, and induces apoptosis. In an HT-29 mouse xenograft model, it inhibits peritoneal tumor growth when administered intraperitoneally at a dose of 150 mg/kg but not when administered orally.² Albendazole inhibits mammalian tubulin polymerization and inhibits binding of [³H]mebendazole to H. contortus L3 larval tubulin (IC₅₀s = 6.9 and 0.21 µM, respectively).³ Formulations containing albendazole have been used in the treatment of tapeworm infections and in a variety of nematode infections in livestock and pets.

1.Theodorides, V.J., Gyurik, R.J., Kingsbury, W.D., et al.Anthelmintic activity of albendazole against liver flukes, tapeworms, lung and gastrointestinal roundwormsExperientia32(6)702-703(1976) 2.Pourgholami, M.H., Akhter, J., Wang, L., et al.Antitumor activity of albendazole against the human colorectal cancer cell line HT-29: In vitro and in a xenograft model of peritoneal carcinomatosisCancer Chemother. Pharmacol.55(5)425-432(2005) 3.Lacey, E.Mode of action of benzimidazolesParasitol. Today6(4)112-115(1990)