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Aligeron Sale

目录号 : GC32558

Aligeron是一种非选择性的prostaglandin(PG)拮抗剂,具有舒张血管的作用。

Aligeron Chemical Structure

Cas No.:70713-45-0

规格 价格 库存 购买数量
1mg
¥893.00
现货
5mg
¥1,785.00
现货
10mg
¥3,035.00
现货
20mg
¥5,355.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

Aligeron is a non-selective prostaglandin (PG) antagonist, and has vasodilatory properties.

Aligeron shows a broad spectrum of antagonistic action against different spasmogens in different isolated organs. The experiments on isolated perfused rabbit artery shows the antagonistic action of aligeron against the vasoconstrictor effects of noradrenaline and adrenaline[1]. The effect of aligeron in vitro lacks selectivity and is probably due to interference with the action of Ca2+[3].

In hypoventilation hypoxia, aligeron (5 mg/kg i.v.) and cinnarizine increase cortical resistance to hypoxia and accelerated the recovery of cortical bioelectrical activity. In KCl- and AMP-induced depressions aligeron shows a protective effect manifested in a decrease of the degree and duration of the depression[2].

[1]. Miyares K, et al. Antagonistic activity of aligeron and papaverine against different smooth muscle stimuli. Methods Find Exp Clin Pharmacol. 1985 Sep;7(9):473-6. [2]. Dimov S, et al. Effect of aligeron and cinnarizine in models of general and local depression of the cortical bioelectrical activity in cats. Methods Find Exp Clin Pharmacol. 1983;5(2):89-95. [3]. Nikolov R, et al. Study on the prostaglandin antagonistic activity of aligeron and piracetam. Methods Find Exp Clin Pharmacol. 1982 Aug-Sep;4(6):387-95.

化学性质

Cas No. 70713-45-0 SDF
Canonical SMILES C=CCN1CCN(C(C2=CC=CC=C2)C3=CC=CC=C3)CC1
分子式 C20H24N2 分子量 292.42
溶解度 Soluble in DMSO 储存条件 Store at -20°C
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溶解性数据

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1 mg 5 mg 10 mg
1 mM 3.4197 mL 17.0987 mL 34.1974 mL
5 mM 0.6839 mL 3.4197 mL 6.8395 mL
10 mM 0.342 mL 1.7099 mL 3.4197 mL
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