Alisol C 23-acetate (23-O-Acetylalisol C)
(Synonyms: 泽泻醇C-23-醋酸酯,23-O-Acetylalisol C; Alisol C monoacetate) 目录号 : GC34038
A triterpenoid with diverse biological activities
Cas No.:26575-93-9
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >98.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Alisol C monoacetate is a triterpenoid that has been found in Alisma orientale and has diverse biological activities.1,2,3,4 It is active against certain antibiotic-resistant strains of S. aureus, E. faecium, E. coli, and P. aeruginosa (MICs = 2.5-5 ?g/ml) but not against other antibiotic-resistant strains of S. aureus or E. coli (MICs = >256 ?g/ml).2,3 Alisol C monoacetate (1-10 ?M) inhibits osteoclast formation induced by calcitriol in a co-culture of primary rat osteoblasts and primary rat bone marrow cells.4 It reduces trabecular bone loss and serum levels of a variety of cytokines, including TNF-α, IL-6, and IL-1β, in an ovariectomized rat model of osteoporosis when administered at doses of 1 and 2 mg/kg. Alisol C monoacetate (10 and 50 mg/kg) also reduces ear edema in a mouse model of delayed-type hypersensitivity.1
1.Lee, J.H., Kwon, O.S., Jin, H.-G., et al.The rhizomes of Alisma orientale and alisol derivatives inhibit allergic response and experimental atopic dermatitisBiol. Pharm. Bull.35(9)1581-1587(2012) 2.Jin, H.-G., Jin, Q., Kim, A.R., et al.A new triterpenoid from Alisma orientale and their antibacterial effectArch. Pharm. Res.35(11)1919-1926(2012) 3.Li, C., Yan, W., Cui, E., et al.Anti-bacterial effect of phytoconstituents isolated from Alimatis rhizomaAppl. Biol. Chem.64(9)1-5(2021) 4.Jia, X., Zhu, H., Li, G., et al.Anti-osteoporotic effects of alisol C 23-acetate via osteoclastogenesis inhibitionBiomed. Pharmacother.137111321(2021)
| Cas No. | 26575-93-9 | SDF | |
| 别名 | 泽泻醇C-23-醋酸酯,23-O-Acetylalisol C; Alisol C monoacetate | ||
| Canonical SMILES | C[C@@]([C@]([C@@H](O)C1)([H])[C@]2(CCC3=O)C)(CC[C@@]2([H])C3(C)C)[C@](C1=C([C@H](C)C[C@@H]([C@]4([H])C(C)(C)O4)OC(C)=O)C5=O)(C5)C | ||
| 分子式 | C32H48O6 | 分子量 | 528.72 |
| 溶解度 | DMSO : 25 mg/mL (47.28 mM; ultrasonic and warming and heat to 60°C) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 1.8914 mL | 9.4568 mL | 18.9136 mL |
| 5 mM | 0.3783 mL | 1.8914 mL | 3.7827 mL |
| 10 mM | 0.1891 mL | 0.9457 mL | 1.8914 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。