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Almitrine mesylate (Almitrine bismesylate) Sale

(Synonyms: 甲磺酸阿米三嗪,Almitrine bismesylate; Almitrine bismethanesulfonate; Almitrine dimesylate) 目录号 : GC30891

Almitrine mesylate (Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesylate), a pharmacologically unique respiratory stimulant, acts as an agonist of peripheral chemoreceptors located on the carotid bodies. Almitrine mesylate inhibits the activity of Ca2+-dependent K+ channel by decreasing its open probability with IC50 of 0.22 μM.

Almitrine mesylate (Almitrine bismesylate) Chemical Structure

Cas No.:29608-49-9

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10mM (in 1mL DMSO)
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10mg
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50mg
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100mg
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Sample solution is provided at 25 µL, 10mM.

Description

Almitrine mesylate (Almitrine bismesylate, Almitrine dimethanesulfonate, Almitrine dimesylate), a pharmacologically unique respiratory stimulant, acts as an agonist of peripheral chemoreceptors located on the carotid bodies. Almitrine mesylate inhibits the activity of Ca2+-dependent K+ channel by decreasing its open probability with IC50 of 0.22 μM.

[1] P D Smith, et al. Drug Intell Clin Pharm. 1987 May;21(5):417-21. [2] J R López-López, et al. Mol Pharmacol. 1998 Feb;53(2):330-9.

实验参考方法

Animal experiment:

Rats[2]8-week-old male spf Wistar rats are used. Rats are anaesthetized with Thiobarbiturate inactin (BYK, 100 mg/kg, i.p.). The interaction of the ventilatory response to hypoxia and an intermittent (2 min on, 1 min break) low-dose (10 μg/kg per min) and high-dose (80 μg/kg per min) infusion of S9581 or Almitrine is tested in control and chronically hypoxic rats. S9581 or Almitrine is infused intravenously (100 μg/ mL). Inspired oxygen levels were controlled by passing oxygen-nitrogen mixtures across the tracheal port at a flow rate of 3-41 min-1[2].

References:

[1]. López-López JR, et al. Effects of Almitrine bismesylate on the ionic currents of chemoreceptor cells from the carotid body. Mol Pharmacol. 1998 Feb;53(2):330-9.
[2]. Bee D, et al. An analysis of the action of an analogue of Almitrine bismesylate in the rat model of hypoxic lung disease. Exp Physiol. 1992 Nov;77(6):819-28.

化学性质

Cas No. 29608-49-9 SDF
别名 甲磺酸阿米三嗪,Almitrine bismesylate; Almitrine bismethanesulfonate; Almitrine dimesylate
Canonical SMILES C=CCNC1=NC(N(CC2)CCN2C(C3=CC=C(F)C=C3)C4=CC=C(F)C=C4)=NC(NCC=C)=N1.O=S(O)(C)=O.O=S(O)(C)=O
分子式 C28H37F2N7O6S2 分子量 669.76
溶解度 DMSO : 125 mg/mL (186.63 mM) 储存条件 Store at -20°C
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1 mg 5 mg 10 mg
1 mM 1.4931 mL 7.4654 mL 14.9307 mL
5 mM 0.2986 mL 1.4931 mL 2.9861 mL
10 mM 0.1493 mL 0.7465 mL 1.4931 mL
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