Ambroxol-d5 (hydrochloride)

Ambroxol-d₅ is intended for use as an internal standard for the quantification of ambroxol by GC- or LC-MS. Ambroxol is an expectorant and active metabolite of bromhexine.¹ It inhibits the voltage-gated sodium channel Na_v1.2 in isolated dorsal root neurons (IC₅₀ = 110 µM for the rat channel).² Ambroxol decreases short-circuit currents in electrically stimulated isolated canine tracheal epithelial cells when applied submucosally (IC₅₀ = 60 nM).³ It decreases IL-13-induced production of mucin 5AC (MUC5AC) in primary human airway epithelial cells when used at a concentration of 100 µM and inhibits IL-13-induced decreases in the mucociliary transport rate of endogenous particles in the same cells.⁴ Ambroxol (30, 60, or 120 mg/kg) increases phenol red secretion, a marker of expectorant activity, in mice.⁵ Formulations containing ambroxol have been used in the treatment of acute or chronic respiratory conditions.