Amlodipine Besylate
(Synonyms: 苯磺酸氨氯地平; Amlodipine benzenesulfonate) 目录号 : GC13146
An L-type calcium channel blocker
Cas No.:111470-99-6
Sample solution is provided at 25 µL, 10mM.
;)
,-1-7$$$37316672.jpg');)
;)
;)
$$$36806353.jpg');)
;33(7)%EF%BC%9A546-561$$$37156877.jpg');)
;)
;)
;)
%201124-1138.$$$35908550.jpg');)
%20766-780.$$$37100057.jpg');)
%20418-432.$$$36893736.jpg');)
%EF%BC%9A-240-255.$$$35108512.jpg');)
533-545$$$36543525.jpg');)
%201-13.$$$36600053.jpg');)
;)
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Amlodipine besylate is a long-acting Ca2+ channel blocker that reduce blood pressure as an antihypertensive drugs.
Calcium channel is an ion channel that selectively permeable to calcium ions. It serves vital functions in cellular signal transduction.
In cortical neurons, treatment of amlodipine besylate (<= 5 um) rescued the viability of H(2) O(2) injured cell and elevated the free radicals levels. Amlodipine besylate exhibits neuroptorective effects, such as reducing oxidative stress, promoting survival signals and blocking death signals. [1] It also showed proliferative effect on human epidermoid carcinoma A431 cells.[2]
In patient with exertional angina, amlodipine besylate reduced the total peripheral resistance and myocardial oxygen demand. In cat orally treated with amlodipine besylate daily, the average indirect systolic blood pressure were decreased without significant body weight/serum creatinine/potassium concentrations changes. [3]
References:
[1] Lee YJ, Park HH, Koh SH, Choi NY, Lee KY. Amlodipine besylate and amlodipine camsylate prevent cortical neuronal cell death induced by oxidative stress. J Neurochem. 2011 Dec;119(6):1262-70. doi: 10.1111/j.1471-4159.2011.07529.x.
[2] Yoshida J, Ishibashi T, Nishio M. Antiproliferative effect of Ca2+ channel blockers on human epidermoid carcinoma A431 cells. Eur J Pharmacol. 2003 Jul 4;472(1-2):23-31.
[3] Henik RA, Snyder PS, Volk LM. Treatment of systemic hypertension in cats with amlodipine besylate. J Am Anim Hosp Assoc. 1997 May-Jun;33(3):226-34.
| Cas No. | 111470-99-6 | SDF | |
| 别名 | 苯磺酸氨氯地平; Amlodipine benzenesulfonate | ||
| 化学名 | benzenesulfonic acid;3-O-ethyl 5-O-methyl 2-(2-aminoethoxymethyl)-4-(2-chlorophenyl)-6-methyl-1,4-dihydropyridine-3,5-dicarboxylate | ||
| Canonical SMILES | CCOC(=O)C1=C(NC(=C(C1C2=CC=CC=C2Cl)C(=O)OC)C)COCCN.C1=CC=C(C=C1)S(=O)(=O)O | ||
| 分子式 | C20H25ClN2O5.C6H6O3S | 分子量 | 567.05 |
| 溶解度 | ≥ 26.05mg/mL in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
||
| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
 |
1 mg | 5 mg | 10 mg |
| 1 mM | 1.7635 mL | 8.8176 mL | 17.6351 mL |
| 5 mM | 0.3527 mL | 1.7635 mL | 3.527 mL |
| 10 mM | 0.1764 mL | 0.8818 mL | 1.7635 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。