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Ampalex Sale

(Synonyms: 安帕来斯; BDP 12) 目录号 : GC13164

An AMPA receptor modulator

Ampalex Chemical Structure

Cas No.:154235-83-3

规格 价格 库存 购买数量
10mM (in 1mL DMSO)
¥609.00
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100mg
¥746.00
现货

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Sample solution is provided at 25 µL, 10mM.

Description

Ampalex (Ampakine CX516; CX516; BDP 12) is an ampakine and nootropic that acts as an AMPA receptor positive allosteric modulator as a treatment for Alzheimer's disease, schizophrenia and mild cognitive impairment (MCI). IC50 value: Target: AMPA receptorAmpalex ameliorates functional deficits in AMPA receptors in a hippocampal slice model of protein accumulation. Researches suggest that AMPA receptors may be potential pharmaceutical targets for the treatment of neurodegenerative diseases, and highlights AMPAkines, in particular, as possible therapeutic agents.

References:
[1]. Broberg BV, Glenth j BY, Dias R, et al. Reversal of cognitive deficits by an ampakine (CX516) and sertindole in two animal models of schizophrenia--sub-chronic and early postnatal PCP treatment in attentional set-shifting. Psychopharmacology (Berl). 2009
[2]. Kanju PM, Parameshwaran K, Sims C, et al. Ampakine CX516 ameliorates functional deficits in AMPA receptors in a hippocampal slice model of protein accumulation. Exp Neurol. 2008 Nov;214(1):55-61.
[3]. Goff DC, Lamberti JS, Leon AC, et al. A placebo-controlled add-on trial of the Ampakine, CX516, for cognitive deficits in schizophrenia. Neuropsychopharmacology. 2008 Feb;33(3):465-72.
[4]. O'Neill MJ, Witkin JM. AMPA receptor potentiators: application for depression and Parkinson's disease. Curr Drug Targets. 2007 May;8(5):603-20.
[5]. Johnson SA, Simmon VF. Randomized, double-blind, placebo-controlled international clinical trial of the Ampakine CX516 in elderly participants with mild cognitive impairment: a progress report. J Mol Neurosci. 2002 Aug-Oct;19(1-2):197-200.

化学性质

Cas No. 154235-83-3 SDF
别名 安帕来斯; BDP 12
化学名 piperidin-1-yl(quinoxalin-6-yl)methanone
Canonical SMILES C1CCN(CC1)C(=O)C2=CC3=NC=CN=C3C=C2
分子式 C14H15N3O 分子量 241.29
溶解度 ≥ 13.45 mg/mL in DMSO, ≥ 92 mg/mL in EtOH, ≥ 24.1 mg/mL in Water with gentle warming 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 4.1444 mL 20.722 mL 41.4439 mL
5 mM 0.8289 mL 4.1444 mL 8.2888 mL
10 mM 0.4144 mL 2.0722 mL 4.1444 mL
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