Amyloid Beta-Peptide (12-28) (human)

Amyloid Beta-Peptide (12-28) (human) is a peptide fragment of amyloid beta protein (1-42) (Aβ (1-42)) ^[1]. One of the neuropathological features of Alzheimer's disease (AD) is the presence of amyloid deposits in senile plaques and in blood vessel walls ^[2]. Amyloid Beta-Peptide (12-28) was used as an internal standard ^[1].

Amyloid Beta-Peptide (12-28) (human) could efficiently suppress the formation of the α7nAChR.Aβ (1-42) complex. Using human brain tissues and cells that overexpress either the α7 nicotinic acetylcholine receptor (α7nAChR) or amyloid precursor protein as the starting material, Aβ (1-42) and α7nAChR can be co-immunoprecipitated by the respective specific antibodies, suggesting that they are tightly associated ^[3].

References:
[1]. Wang R, Sweeney D, Gandy SE, Sisodia, SS (1996) The profile of soluble amyloid b protein in cultured cell media. Detection and quantificaiton of amyloid β protein and variants by immunoprecipitation-mass spectrometry. J Biol Chem 271:31894-31902.
[2]. Terry R. D., and Davies P.(1983) Aging of the Brain (Samuel, D., Algeri, S.,Gershon ,S., Grimm, V., and Toffano, G., eds) Vol. 22, pp. 47-59, Raven Press
[3]. Wang, H. Y. et al. β-Amyloid1-42 binds to α7 nicotinic acetylcholine receptor with high affinity. Implications for Alzheimer's disease pathology. J. Biol. Chem. 275, 5626-5632 (2000).

Amyloid Beta-Peptide (12-28)（人）是 Amyloid Beta 蛋白 (1-42) (Aβ (1-42)) ^[1] 的肽片段。阿尔茨海默病 (AD) 的神经病理学特征之一是老年斑和血管壁中存在淀粉样沉积物 ^[2]。 Amyloid Beta-Peptide (12-28) 用作内标^[1]。

Amyloid Beta-Peptide (12-28)（人）可有效抑制 α7nAChR.Aβ (1-42) 复合物的形成。使用过表达 α7 烟碱乙酰胆碱受体 (α7nAChR) 或淀粉样蛋白前体蛋白的人脑组织和细胞作为起始材料，Aβ (1-42) 和 α7nAChR 可以通过各自的特异性抗体进行免疫共沉淀，表明它们紧密结合关联的^[3]。