Amyloid Precursor C-Terminal Peptide

Amyloid precursor c-terminal peptide (APP) (C86H118N20O27S) has the amino acid sequence Gly-Tyr-Glu-Asn-Pro-Thr-Tyr-Lys-Phe-Phe-Glu-Gln-Met-Gln-Asn. Although it has been implicated as a regulator of synapse formation, neural plasticity and iron export, the primary function of APP is not known. APP is best known as the precursor molecule whose proteolysis generates beta amyloid (Aǂ), a 37 to 49 amino acid peptide whose amyloid fibrillar form is the primary component of amyloid plaques found in the brains of Alzheimer's disease patients. So it is a possible contributor to Alzheimer¤s pathogenesis through MAPKs- and NF-NJB-dependent astrocytosis. Recently, APP origin was demonstrated with arthritogenic animals. Also, it induces secondary inflammation, which may cause local damage.

References:
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3. Duce JA et al (2010). "Iron-Export Ferroxidase Activity of ǂ- Amyloid Precursor Protein Is Inhibited by Zinc in Alzheimer's Disease". Cell 142 (6): 857-67.
4. Subramanian S (January 2010). "Immunological and Biochemical factors in amyloidosis of adjuvant arthritic rats". Asian Journal of Experimental Biological Sciences 24 (1): 101-105.