Chlorpyrifos-d10
(Synonyms: 氘代毒死蜱-D10) 目录号 : GC47083
An internal standard for the quantification of chlorpyrifos
Cas No.:285138-81-0
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >99.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Chlorpyrifos-d10 is intended for use as internal standard for the quantification of chlorpyrifos by GC- or LC-MS. Chlorpyrifos is an organophosphate insecticide.1,2 It is lethal to A. melinus, G. ashmeadi, E. eremicus, and E. formosa adults (LC50s = 0.8, 6, 12, and 17 ng/ml, respectively).1 Chlorpyrifos induces mortality in O. insidiosus adults when applied to corn, sorghum, and alfalfa plants.2 It is toxic to mice (LD50 = 155 mg/kg).3 Postnatal day 11 to 14 exposure to chlorpyrifos (3 mg/kg) decreases nest building and defense behaviors in adult female mice.4 Formulations containing chlorpyrifos have been used in the control of insects in agriculture.
1.Prabhaker, N., Morse, J.G., Castle, S.J., et al.Toxicity of seven foliar insecticides to four insect parasitoids attacking citrus and cotton pestsJ. Econ. Entomol.100(4)1053-1061(2007) 2.Al-Deeb, M.A., Wilde, G.E., and Zhu, K.Y.Effect of insecticides used in corn, sorghum, and alfalfa on the predator Orius insidiosus (Hemiptera: Anthocoridae)J. Econ. Entomol.94(6)1353-1360(2001) 3.Guo, J.-X., Wu, J.J.-Q., Wight, J.B., et al.Mechanistic insight into acetylcholinesterase inhibition and acute toxicity of organophosphorus compounds: A molecular modeling studyChem. Res. Toxicol.19(2)209-216(2006) 4.Venerosi, A., Cutuli, D., Colonnello, V., et al.Neonatal exposure to chlorpyrifos affects maternal responses and maternal aggression of female mice in adulthoodNeurotoxicol. Teratol.30(6)468-474(2008)
| Cas No. | 285138-81-0 | SDF | |
| 别名 | 氘代毒死蜱-D10 | ||
| Canonical SMILES | ClC1=NC(OP(OC([2H])([2H])C([2H])([2H])[2H])(OC([2H])([2H])C([2H])([2H])[2H])=S)=C(Cl)C=C1Cl | ||
| 分子式 | C9HCl3D10NO3PS | 分子量 | 360.6 |
| 溶解度 | H2O : 100 mg/mL (277.28 mM; Need ultrasonic); DMSO : 50 mg/mL (138.64 mM; Need ultrasonic) | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 2.7732 mL | 13.8658 mL | 27.7316 mL |
| 5 mM | 0.5546 mL | 2.7732 mL | 5.5463 mL |
| 10 mM | 0.2773 mL | 1.3866 mL | 2.7732 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
[Determination of 18 pesticide residues in red wine by ultra high performance liquid chromatography-high resolution mass spectrometry with isotope dilution technique]
Se Pu 2014 May;32(5):485-92.PMID:25185308DOI:10.3724/sp.j.1123.2014.01012
A method for the simultaneous determination of 18 pesticide residues in red wine was developed using ultra high performance liquid chromatography-high resolution mass spectrometry (UPLC-HRMS) with isotope dilution technique. The red wine samples were extracted with acetonitrile, and the extracts were cleaned up with dispersive solid phase extraction (dSPE) using the mixture of N-propyl ethylene diamine (PSA) and C18 powder as sorbent. The extracted components were separated on a BEH C18 column by gradient elution. The qualitative and quantitative analyses were operated under full scan/data dependent MS/MS (ddms2) and targeted selective ion monitoring (tSIM) by high resolution mass spectrometry, respectively. Carbendazim-D4, Chlorpyrifos-d10, imidacloprid-D4, methoxyfenozide-D9, pyrimethanil-D5 and tebuconazole-D6 were used as the internal standards to reduce the matrix effects. The response of each pesticide showed a good linearity in the range of 0.5-50 microg/kg with the correlation coefficient more than 0.999. The limits of detection and quantification for the 18 pesticides in the spiked blank red wine were 0.5 microg/kg and 1.0 microg/kg, respectively. The recovery results with spiked blank red wine samples at the levels of 1 to 40 microg/kg were satisfactory with average recoveries of 85.4% - 117.9% and the RSDs of 0.5%-6.1%. The method was applied for the determination of the red wine real samples from the market. Carbendazim, imidacloprid, pyrimethanil, tebuconazole and triadimenol were detected in the samples. The results show that the method is suitable for the rapid screening and quantitative analysis of pesticide residues in red wine.