Andarine
(Synonyms: S-4) 目录号 : GC13685
A selective androgen receptor modulator
Cas No.:401900-40-1
Sample solution is provided at 25 µL, 10mM.
Andarine (S-4) is a selective inhibitor of AR with Ki value of 4 nM [1].
Androgen receptor (AR), also known as nuclear receptor subfamily 3, group C, member 4, is a type of nuclear receptor and plays an important role in DNA-binding transcription factor that regulates gene expression [2].
Andarine is a potent AR inhibitor and has a higher affinity with the reported AR inhibitor S-1, S-2 and S-3. Using a cotransfection system, it was shown that Andarine stimulated AR-mediated transcription as high as 93% at the concentration of 10 nM. [1].
In male Sprague-Dawley rat model, administration of Andarine resulted in the growth in prostate, seminal vesicles, and levator ani muscle at a dose-dependent manner and promoted their weight being maximally to 33.8, 28.2 and 101% of intact controls, respectively. Further, it was revealed that the ED50 value of Andarine functioning on prostate, seminal vesicles, and levator ani muscle was 0.43±0.01, 0.55±0.02, and 0.14±0.01 mg/day [1].
References:
[1]. Yin, D., et al., Pharmacodynamics of selective androgen receptor modulators. J Pharmacol Exp Ther, 2003. 304(3): p. 1334-40.
[2]. Thevis, M., et al., Mass spectrometric characterization of urinary metabolites of the selective androgen receptor modulator S-22 to identify potential targets for routine doping controls. Rapid Commun Mass Spectrom, 2011. 25(15): p. 2187-95.
Cas No. | 401900-40-1 | SDF | |
别名 | S-4 | ||
化学名 | (2S)-3-(4-acetamidophenoxy)-2-hydroxy-2-methyl-N-[4-nitro-3-(trifluoromethyl)phenyl]propanamide | ||
Canonical SMILES | C(=O)NC1=CC=C(C=C1)OCC(C)(C(=O)NC2=CC(=C(C=C2)[N+](=O)[O-])C(F)(F)F)O | ||
分子式 | C19H18F3N3O6 | 分子量 | 441.36 |
溶解度 | ≥ 21mg/mL in DMSO | 储存条件 | Store at -20°C |
General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。 储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。 为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。 |
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Shipping Condition | 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。 |
制备储备液 | |||
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1 mg | 5 mg | 10 mg |
1 mM | 2.2657 mL | 11.3286 mL | 22.6572 mL |
5 mM | 0.4531 mL | 2.2657 mL | 4.5314 mL |
10 mM | 0.2266 mL | 1.1329 mL | 2.2657 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet