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Angiotensin 1/2 (1-9) Sale

(Synonyms: 血管紧张素I,H2N-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-OH ) 目录号 : GP10025

血管收缩药

Angiotensin 1/2 (1-9) Chemical Structure

Cas No.:34273-12-6

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5mg
¥473.00
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10mg
¥746.00
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25mg
¥966.00
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Sample solution is provided at 25 µL, 10mM.

Description

Angiotensin I/II (1-9) is a peptide (ASP-ARG-VAL-TYR-ILE-HIS-PRO-PHE-HIS) containing the amino acids 1-9 that are converted from Angiotensin I/II peptide.

Angiotensin I is formed by the action of renin on angiotensinogen, which has 12 amino acids and is an ǁ-2-globulin produced constitutively and released into the circulation mainly by the liver. Renin cleaves the peptide bond between the leucine (Leu) and valine (Val) residues on angiotensinogen, creating the ten-amino acid peptide angiotensin I. Angiotensin I is converted to angiotensin II (AII) through removal of two C-terminal residues by the enzymeangiotensin-converting enzyme (ACE), primarily through ACE within the lung.

Angiotensin is a peptide hormone that causes vasoconstriction and a subsequent increase in blood pressure. Angiotensin also stimulates the release of aldosterone, which promotes sodium retention in the distal nephron so that drives blood pressure up.

References:
1. Basso N, Terragno NA (December 2001). "History about the discovery of the renin-angiotensin system". Hypertension 38 (6): 1246-9.
2. Richard A. Preston. et. (1998). pAge-Race Subgroup Compared With Renin Profile as Predictors of Blood Pressure Response to Antihypertensive Therapyq. JAMA. 1998;280(13):1168-1172.
3. Williams GH, Dluhy RG (2008). "Chapter 336: Disorders of the Adrenal Cortex". In Loscalzo J, Fauci AS, Braunwald E, Kasper DL, Hauser SL, Longo DL. Harrison's principles of internal medicine. McGraw-Hill Medical.

化学性质

Cas No. 34273-12-6 SDF
别名 血管紧张素I,H2N-Asp-Arg-Val-Tyr-Ile-His-Pro-Phe-His-OH
化学名 Angiotensin 1/2 (1-9)
Canonical SMILES CCC(C)C(C(=O)NC(CC1=CN=CN1)C(=O)N2CCCC2C(=O)NC(CC3=CC=CC=C3)C(=O)NC(CC4=CN=CN4)C(=O)O)NC(=O)C(CC5=CC=C(C=C5)O)NC(=O)C(C(C)C)NC(=O)C(CCCN=C(N)N)NC(=O)C(CC(=O)O)N
分子式 C56H78N16O13 分子量 1183.32
溶解度 ≥ 118.3mg/mL in DMSO 储存条件 Store at -20°C
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储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 0.8451 mL 4.2254 mL 8.4508 mL
5 mM 0.169 mL 0.8451 mL 1.6902 mL
10 mM 0.0845 mL 0.4225 mL 0.8451 mL
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