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Anifrolumab

目录号 : GC68343

Anifrolumab 是一种 I 型干扰素 (IFN) 受体拮抗剂,是一种人源单克隆抗体。Anifrolumab 能阻断 I 型干扰素的活性,可用于系统性红斑狼疮 (SLE) 的研究。

Anifrolumab Chemical Structure

Cas No.:1326232-46-5

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5mg
¥4,860.00
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10mg
¥7,650.00
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Sample solution is provided at 25 µL, 10mM.

Description

Anifrolumab is a type I interferon (IFN) receptor antagonist, a human monoclonal antibody. Anifrolumab blocks the activity of type I interferon. Anifrolumab can be used in systemic lupus erythematosus (SLE) research[1][2].

Anifrolumab (67.7 nM; 20 min) induces sustained reduction of surface IFNAR1 and abrogates STAT1 phosphorylation[2].
Anifrolumab (1 and 10 μg/mL; 6 or 7 d) suppresses differentiation of B cells into plasma cells[2].
Anifrolumab inhibits type I IFN-induced ISRE signaling, with IC50s ranging from 0.004 to 0.3 nM for the IFN-α subtypes, and 0.03 nM and 0.07 nM for IFN-β and IFN-ω, respectively[2].
Anifrolumab (67.7 nM) dose-dependently inhibits IFN-α production from pDCs in response to CpG-A or DNA-IC stimulation, inhibiting 87-95% of IFN-α production[2].

Western Blot Analysis[2]

Cell Line: Peripheral blood mononuclear cells (PBMCs)
Concentration: 67.7 nM
Incubation Time: 20 min
Result: Abrogated IFN-α2-dependent and pDC supernatant-dependent STAT1 phosphorylation.

Cell Differentiation Assay[2]

Cell Line: Plasmacytoid dendritic cell (pDC)
Concentration: 1 and 10 μg/mL
Incubation Time: 6 or 7 days
Result: Inhibited pDC-mediated plasma cell differentiation in a dose-dependent manner, with a mean 76% reduction in plasma cell number relative to control antibody.

[1]. Furie R, et al. Anifrolumab, an Anti-Interferon-α Receptor Monoclonal Antibody, in Moderate-to-Severe Systemic Lupus Erythematosus. Arthritis Rheumatol. 2017 Feb;69(2):376-386.
[2]. Riggs JM, et al. Characterisation of anifrolumab, a fully human anti-interferon receptor antagonist antibody for the treatment of systemic lupus erythematosus. Lupus Sci Med. 2018 Apr 5;5(1):e000261.

化学性质

Cas No. 1326232-46-5 SDF Download SDF
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