Anti-Mouse IL-6 Antibody (MP5-20F3)

Anti-Mouse IL-6 Antibody (MP5-20F3) is a rat-derived IgG1, κ type antibody inhibitor, targeting to mouse IL-6.

In Vitro, The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties^[1].

References:
[1]. Goulet DR, Atkins WM. Considerations for the Design of Antibody-Based Therapeutics. J Pharm Sci. 2020 Jan;109(1):74-103.

Anti-Mouse IL-6 Antibody (MP5-20F3) 是大鼠来源的、抗小鼠 IL-6 的 IgG1, κ 抗体抑制剂。

在体外，抗体框架具有稳定性、特异性和适应性，同时具有结合抗原和内源免疫受体。 单克隆抗体具有几种衍生物，包括双特异性抗体、抗体-药物缀合物和抗体片段，在免疫学和肿瘤学等领域具有显著效果。 设计抑制性抗体时，需要注意包括抗原特异性可变区的鉴定、表达系统的选择、多特异性形式的使用以及基于片段化、寡聚化或与其他功能部分缀合的抗体衍生物^[1]。