Apigenin 7-O-Glucuronide (hydrate)

Apigenin 7-O-glucuronide is a flavonoid that has been found in J. sigillata and has diverse biological activities.^1,2,3,4 It inhibits matrix metalloproteinase-3 (MMP-3), MMP-8, MMP-9, and MMP-13 (IC₅₀s = 12.87, 22.39, 17.52, and 0.27 μM, respectively).^1,2,3,4 Apigenin 7-O-glucuronide also inhibits protein tyrosine phosphatase 1B (PTP1B), acetylcholinesterase (AChE), and aldose reductase with IC₅₀ values of 7.14, 62.96, and 107.1 µM, respectively.^2,3 It inhibits LPS-induced production of nitric oxide, prostaglandin E₂ , and TNF-α in RAW 264.7 cells when used at a concentration of 100 µM.⁴ Apigenin 7-O-glucuronide (5 or 10 mg/kg) improves survival in a mouse model of septic shock induced by LPS.

1.Crasci, L., Basile, L., Panico, A., et al.Correlating in vitro target-oriented screening and docking: Inhibition of matrix metalloproteinases activities by flavonoidsPlanta Med.83(11)901-911(2017) 2.Nguyen, D.H., Seo, U.M., Zhao, B.T., et al.Ellagitannin and flavonoid constituents from Agrimonia pilosa ledeb. with their protein tyrosine phosphatase and acetylcholinesterase inhibitory activitiesBioorg. Chem.72293-300(2017) 3.Yoo, N.H., Jang, D.S., Yoo, J.L., et al.Erigeroflavanone, a flavanone derivative from the flowers of Erigeron annuus with protein glycation and aldose reductase inhibitory activityJ. Nat. Prod.71(4)713-715(2008) 4.Hu, W., Wang, X., Wu, L., et al.Apigenin-7-O-β-D-glucuronide inhibits LPS-induced inflammation through the inactivation of AP-1 and MAPK signaling pathways in RAW 264.7 macrophages and protects mice against endotoxin shockFood Funct.7(2)1002-1013(2016)