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Aprotinin Protein

目录号 : GP22752

Aprotinin

Aprotinin Protein Chemical Structure

规格 价格 库存 购买数量
100mg
¥2,310.00
5-10工作日
250mg
¥4,620.00
5-10工作日
1g
¥12,600.00
5-10工作日

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Sample solution is provided at 25 µL, 10mM.

Description

Aprotinin is a natural proteinase inhibitor polypeptide consisting of fifty-eight amino acids {C284H432N84O79S7} arranged in a single polypeptide chain, cross-linked by three disulfide bridges and having a molecular mass of 6512.

Product Data

Purity Source Bovine Lung.
Phycical Appearance Sterile Filtered White lyophilized (freeze-dried) powder. Shipping Condition Shipped at Room temp.
Synonyms Pancreatic trypsin inhibitor; Basic protease inhibitor; BPI; BPTI; Aprotinin; AP.
Solubility It is recommended to reconstitute the lyophilized Aprotinin in sterile 18MΩ-cm H2O not less than 100µg/ml, which can then be further diluted to other aqueous solutions.
Stability Lyophilized Aprotinin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution Aprotinin should be stored at 4°C between 2-7 days and for future use below -18°C .For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.
Formulation The protein (1mg/ml) was lyophilized with no additives.

Introduction

Aprotinin inhibits the activity of several proteolytic enzymes such as chymotrypsin, kallikrein, plasmin and trypsin. Aprotinin is present in blood and in most tissues, with a high concentration in lung. Aprotinin inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. In platelets, aprotinin reduces glycoprotein loss (e.g., GpIb, GpIIb/IIIa), while in granulocytes it prevents the expression of pro-inflammatory adhesive glycoproteins (e.g., CD11b).

Stability

Lyophilized Aprotinin although stable at room temperature for 3 weeks, should be stored desiccated below -18°C . Upon reconstitution Aprotinin should be stored at 4°C between 2-7 days and for future use below -18°C .For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA).Please prevent freeze-thaw cycles.

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