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Aramchol Sale

(Synonyms: Aramchol; C20-FABAC) 目录号 : GC19435

A fatty acid bile acid conjugate

Aramchol Chemical Structure

Cas No.:246529-22-6

规格 价格 库存 购买数量
1mg 待询 待询
5mg
¥720.00
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10mg
¥1,260.00
现货
25mg
¥2,610.00
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Sample solution is provided at 25 µL, 10mM.

产品文档

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产品描述

Aramchol, also known as arachidyl amido cholanoic acid, is a conjugate of arachidic acid and cholic acid . It reduces ex vivo cholesterol crystallization in native human bile and dissolves pre-formed cholesterol crystals in a dose-dependent manner. In vivo, aramchol completely prevents the formation of cholesterol crystals and gallstones in mice fed a lithogenic, high-fat diet. It also prevents lithogenic, high-fat diet-induced fatty liver in mice, rats, and hamsters. Formulations containing aramchol have been investigated clinically for the treatment of non-alcoholic fatty liver disease (NAFLD).

References:
[1]. Gilat, T., Leikin-Frenkel, A., Goldiner, I., et al. Arachidyl amido cholanoic acid (Aramchol) is a cholesterol solubilizer and prevents the formation of cholesterol gallstones in inbred mice Lipids 36(10), 1135-1140 (2001).
[2]. Gilat, T., Leikin-Frenkel, A., Goldiner, I., et al. Prevention of diet-induced fatty liver in experimental animals by the oral administration of a fatty acid bile acid conjugate (FABAC) Hepatology 38(2), 436-442 (2003).
[3]. Safadi, R., Konikoff, F.M., Mahamid, M., et al. The fatty acid-bile acid conjugate Aramchol reduces liver fat content in patients with nonalcoholic fatty liver disease Clin. Gastroenterol. Hepatol. 12(12), 2085-2091 (2014).

Chemical Properties

Cas No. 246529-22-6 SDF
别名 Aramchol; C20-FABAC
Canonical SMILES C[C@H](CCC(O)=O)[C@@]1([H])CC[C@@]2([H])[C@]3([H])[C@H](O)C[C@]4([H])C[C@@H](NC(CCCCCCCCCCCCCCCCCCC)=O)CC[C@]4(C)[C@@]3([H])C[C@H](O)[C@@]21C
分子式 C44H79NO5 分子量 702.1
溶解度 DMF: 30 mg/ml,DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml,DMSO: 20 mg/ml,Ethanol: 20 mg/ml 储存条件 Store at -20°C
General tips 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液;一旦配成溶液,请分装保存,避免反复冻融造成的产品失效。
储备液的保存方式和期限:-80°C 储存时,请在 6 个月内使用,-20°C 储存时,请在 1 个月内使用。
为了提高溶解度,请将管子加热至37℃,然后在超声波浴中震荡一段时间。
Shipping Condition 评估样品解决方案:配备蓝冰进行发货。所有其他可用尺寸:配备RT,或根据请求配备蓝冰。

溶解性数据

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1 mg 5 mg 10 mg
1 mM 1.4243 mL 7.1215 mL 14.243 mL
5 mM 0.2849 mL 1.4243 mL 2.8486 mL
10 mM 0.1424 mL 0.7121 mL 1.4243 mL
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