Arecoline hydrobromide
(Synonyms: 氢溴酸槟榔碱) 目录号 : GC10264
Muscarinic acetylcholine receptor agonist
Cas No.:300-08-3
Sample solution is provided at 25 µL, 10mM.
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Arecoline hydrobromide is a nicotinic acids-based alkaloid and partial agonist of muscarinic acetylchiline M1, M2, M3 and M4 receptors. The LD50 of subcutaneous injection value is 100 mg/kg in mouse [1].
Arecoline hydrobromide has been suggested to have electrophysiological effects on ventricular myocytes. Arecoline hydrobromide has shown the significant inhibitory effect on hERG current with the IC50 value of 9.55μmol/L. Furthermore, Arecoline hydrobromide has demonstrated the concentration- , time- and voltage-dependent characteristics of IhERG inhibition in the patch clamp experiments. Apart from these, Arecoline hydrobromide has been exhibited to significant change in the amount of steady-state blockade at stimulation frequencies. It has been shown frequency-dependent characteristics inhibition of IhERG by Arecoline hydrobromide [1].
References:
[1] Zhao XY1, Liu YQ, Fu YC, Xu B, Gao JL, Zheng XQ, Lin M, Chen MY, Li Y. Frequency- and state-dependent blockade of human ether-a-go-go-related gene K+ channel by arecoline hydrobromide. Chin Med J (Engl). 2012 Mar;125(6):1068-75.
| Cas No. | 300-08-3 | SDF | |
| 别名 | 氢溴酸槟榔碱 | ||
| 化学名 | methyl 1-methyl-3,6-dihydro-2H-pyridine-5-carboxylate;hydrobromide | ||
| Canonical SMILES | CN1CCC=C(C1)C(=O)OC.Br | ||
| 分子式 | C8H14BrNO2 | 分子量 | 236.11 |
| 溶解度 | ≥ 11.8mg/mL in DMSO | 储存条件 | Store at -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 4.2353 mL | 21.1766 mL | 42.3531 mL |
| 5 mM | 0.8471 mL | 4.2353 mL | 8.4706 mL |
| 10 mM | 0.4235 mL | 2.1177 mL | 4.2353 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。
Quality Control & SDS
- View current batch:
- Purity: >99.50%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet