Artepillin C
(Synonyms: 3,5-Diprenyl-4-hydroxy Cinnamic Acid,3,5-Diprenyl-p-hydroxy Cinnamic Acid,3,5-Diprenyl-para-hydroxy Cinnamic Acid,3,5-Diprenyl-4-Coumaric Acid,3,5-Diprenyl-p-Coumaric Acid,3,5-Diprenyl-para-Coumaric Acid) 目录号 : GC91675Artepillin C is a prenylated cinnamic acid that has been found in B. grisebachii and has diverse biological activities.
Cas No.:72944-19-5
Sample solution is provided at 25 µL, 10mM.
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Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Artepillin C is a prenylated cinnamic acid that has been found in B. grisebachii and has diverse biological activities.1,2,3,4,5,6 It selectively inhibits aldo-keto reductase 1C3 (AKR1C3; IC50 = 1 µM), also known as prostaglandin F synthase, over AKR1C1, AKR1C2, and AKR1C4 at 100 µM.[1] It also inhibits lipid peroxidation in isolated human erythrocytes.[2] Artepillin C (10 µM) induces calcium influx in HEK293T cells expressing human transient receptor potential ankyrin 1 (TRPA1), an effect that can be blocked by the TRPA1 inhibitor HC-030031 .[3] It is cytotoxic to HT-1080 fibrosarcoma and 26-L5 colon cancer cells (IC50s = 45.47 and 59.32 µg/ml, respectively).[4] Artepillin C is active against C. albicans, E. floccosum, T. rubrum, methicillin-sensitive S. aureus, and methicillin-resistant S. aureus (MRSA; MICs = 250, 50, 125, 250, and 250 µg/ml, respectively).[5] In vivo, artepillin C (1 and 10 mg/kg) decreases carrageenan-induced peritoneal leukocyte infiltration in mice.[6]
References:
[1].Endo, S., Matsunaga, T., Kanamori, A., et al.Selective inhibition of human type-5 17β-hydroxysteroid dehydrogenase (AKR1C3) by baccharin, a component of Brazilian propolisJ. Nat. Prod.75(4)716-721(2012).
[2].Tapia, A., Rodriguez, J., Theoduloz, C., et al.Free radical scavengers and antioxidants from Baccharis grisebachiiJ. Ethnopharmacol.95(2-3)155-161(2004).
[3].Hata, T., Tazawa, S., Ohta, S., et al.Artepillin C, a major ingredient of Brazilian propolis, induces a pungent taste by activating TRPA1 channelsPLoS One7(11)e48072(2012).
[4].Banskota, A.H., Tezuka, Y., Prasain, J.K., et al.Chemical constituents of brazilian propolis and their cytotoxic activitiesJ. Nat. Prod.61(7)896-900(1998).
[5].Feresin, G.E., Tapia, A., Gimenez, A., et al.Constituents of the Argentinian medicinal plant Baccharis grisebachii and their antimicrobial activityJ. Ethnopharmacol.89(1)73-80(2003).
[6].Paulino, N., Abreu, S.R., Uto, Y., et al.Anti-inflammatory effects of a bioavailable compound, Artepillin C, in Brazilian propolisEur. J. Pharmacol.587(1-3)296-301(2008).
| Cas No. | 72944-19-5 | SDF | Download SDF |
| 别名 | 3,5-Diprenyl-4-hydroxy Cinnamic Acid,3,5-Diprenyl-p-hydroxy Cinnamic Acid,3,5-Diprenyl-para-hydroxy Cinnamic Acid,3,5-Diprenyl-4-Coumaric Acid,3,5-Diprenyl-p-Coumaric Acid,3,5-Diprenyl-para-Coumaric Acid | ||
| 分子式 | C19H24O3 | 分子量 | 300.4 |
| 溶解度 | Acetonitrile: Soluble,DMSO: Soluble | 储存条件 | -20°C |
| General tips | 请根据产品在不同溶剂中的溶解度选择合适的溶剂配制储备液；一旦配成溶液，请分装保存，避免反复冻融造成的产品失效。 储备液的保存方式和期限：-80°C 储存时，请在 6 个月内使用，-20°C 储存时，请在 1 个月内使用。 为了提高溶解度，请将管子加热至37℃，然后在超声波浴中震荡一段时间。 |
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| Shipping Condition | 评估样品解决方案：配备蓝冰进行发货。所有其他可用尺寸：配备RT，或根据请求配备蓝冰。 | ||
| 制备储备液 | |||
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1 mg | 5 mg | 10 mg |
| 1 mM | 3.3289 mL | 16.6445 mL | 33.2889 mL |
| 5 mM | 0.6658 mL | 3.3289 mL | 6.6578 mL |
| 10 mM | 0.3329 mL | 1.6644 mL | 3.3289 mL |
| 第一步：请输入基本实验信息（考虑到实验过程中的损耗，建议多配一只动物的药量） | ||||||||||
| 给药剂量 | mg/kg |  |
动物平均体重 | g | |
每只动物给药体积 | ul | |
动物数量 | 只 |
| 第二步：请输入动物体内配方组成（配方适用于不溶于水的药物；不同批次药物配方比例不同，请联系GLPBIO为您提供正确的澄清溶液配方） | ||||||||||
| % DMSO % % Tween 80 % saline | ||||||||||
| 计算重置 | ||||||||||
计算结果:
工作液浓度： mg/ml；
DMSO母液配制方法： mg 药物溶于 μL DMSO溶液（母液浓度 mg/mL，
体内配方配制方法：取 μL DMSO母液，加入 μL PEG300，混匀澄清后加入μL Tween 80，混匀澄清后加入 μL saline，混匀澄清。
1. 首先保证母液是澄清的；
2.
一定要按照顺序依次将溶剂加入，进行下一步操作之前必须保证上一步操作得到的是澄清的溶液，可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。