Ascorbyl Tetraisopalmitate
(Synonyms: 四己基癸醇抗坏血酸酯) 目录号 : GC49783A vitamin C derivative
Cas No.:183476-82-6
Sample solution is provided at 25 µL, 10mM.
Quality Control & SDS
- View current batch:
- Purity: >95.00%
- COA (Certificate Of Analysis)
- SDS (Safety Data Sheet)
- Datasheet
Ascorbyl tetraisopalmitate is a lipophilic derivative of vitamin C .1,2 It protects against UVB-, hydrogen peroxide-, or tert-butyl hydroperoxide-induced decreases in cell viability in HaCaT keratinocytes when used at a concentration of 100 µM.1 Ascorbyl tetraisopalmitate (20 µM) decreases IL-1α and prostaglandin E2 production in unstimulated and UVB-stimulated HaCaT keratinocytes. Topical application of ascorbyl tetraisopalmitate (1%) increases viable epidermis thickness, stratum corneum water content, and skin smoothness and decreases skin roughness in hairless mice.2 Formulations containing ascorbyl tetraisopalmitate have been used in cosmetic products as skin-lightening agents.
1.Ochiai, Y., Kaburagi, S., Obayashi, K., et al.A new lipophilic pro-vitamin C, tetra-isopalmitoyl ascorbic acid (VC-IP), prevents UV-induced skin pigmentation through its anti-oxidative propertiesJ. Dermatol. Sci.44(1)37-44(2006) 2.Maia Campos, P.M.B.G., Gianeti, M.D., Camargo, F.B., Jr., et al.Application of tetra-isopalmitoyl ascorbic acid in cosmetic formulations: Stability studies and in vivo efficacyEur. J. Pharm. Biopharm.82(3)580-586(2012)
制备储备液 | |||
1 mg | 5 mg | 10 mg | |
1 mM | 0.8851 mL | 4.4256 mL | 8.8511 mL |
5 mM | 0.177 mL | 0.8851 mL | 1.7702 mL |
10 mM | 0.0885 mL | 0.4426 mL | 0.8851 mL |
第一步:请输入基本实验信息(考虑到实验过程中的损耗,建议多配一只动物的药量) | ||||||||||
给药剂量 | mg/kg | 动物平均体重 | g | 每只动物给药体积 | ul | 动物数量 | 只 | |||
第二步:请输入动物体内配方组成(配方适用于不溶于水的药物;不同批次药物配方比例不同,请联系GLPBIO为您提供正确的澄清溶液配方) | ||||||||||
% DMSO % % Tween 80 % saline | ||||||||||
计算重置 |
计算结果:
工作液浓度: mg/ml;
DMSO母液配制方法: mg 药物溶于 μL DMSO溶液(母液浓度 mg/mL,
体内配方配制方法:取 μL DMSO母液,加入 μL PEG300,混匀澄清后加入μL Tween 80,混匀澄清后加入 μL saline,混匀澄清。
1. 首先保证母液是澄清的;
2.
一定要按照顺序依次将溶剂加入,进行下一步操作之前必须保证上一步操作得到的是澄清的溶液,可采用涡旋、超声或水浴加热等物理方法助溶。
3. 以上所有助溶剂都可在 GlpBio 网站选购。